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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Non-invasive modulation reduces repetitive behavior in a rat model through the sensorimotor cortico-striatal circuit
|
|---|---|
| Published in |
Translational Psychiatry, January 2018
|
| DOI | 10.1038/s41398-017-0059-5 |
| Pubmed ID | |
| Authors |
Henriette Edemann-Callesen, Bettina Habelt, Franziska Wieske, Mark Jackson, Niranjan Khadka, Daniele Mattei, Nadine Bernhardt, Andreas Heinz, David Liebetanz, Marom Bikson, Frank Padberg, Ravit Hadar, Michael A. Nitsche, Christine Winter |
| Abstract |
Involuntary movements as seen in repetitive disorders such as Tourette Syndrome (TS) results from cortical hyperexcitability that arise due to striato-thalamo-cortical circuit (STC) imbalance. Transcranial direct current stimulation (tDCS) is a stimulation procedure that changes cortical excitability, yet its relevance in repetitive disorders such as TS remains largely unexplored. Here, we employed the dopamine transporter-overexpressing (DAT-tg) rat model to investigate behavioral and neurobiological effects of frontal tDCS. The outcome of tDCS was pathology dependent, as anodal tDCS decreased repetitive behavior in the DAT-tg rats yet increased it in wild-type (wt) rats. Extensive deep brain stimulation (DBS) application and computational modeling assigned the response in DAT-tg rats to the sensorimotor pathway. Neurobiological assessment revealed cortical activity changes and increase in striatal inhibitory properties in the DAT-tg rats. Our findings show that tDCS reduces repetitive behavior in the DAT-tg rat through modulation of the sensorimotor STC circuit. This sets the stage for further investigating the usage of tDCS in repetitive disorders such as TS. |
X Demographics
The data shown below were collected from the profiles of 8 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 38% |
| France | 1 | 13% |
| Japan | 1 | 13% |
| Italy | 1 | 13% |
| Unknown | 2 | 25% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 50% |
| Scientists | 3 | 38% |
| Practitioners (doctors, other healthcare professionals) | 1 | 13% |
Mendeley readers
The data shown below were compiled from readership statistics for 64 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 64 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 10 | 16% |
| Researcher | 10 | 16% |
| Student > Master | 9 | 14% |
| Student > Bachelor | 8 | 13% |
| Professor | 4 | 6% |
| Other | 7 | 11% |
| Unknown | 16 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 12 | 19% |
| Psychology | 8 | 13% |
| Engineering | 8 | 13% |
| Medicine and Dentistry | 7 | 11% |
| Biochemistry, Genetics and Molecular Biology | 4 | 6% |
| Other | 8 | 13% |
| Unknown | 17 | 27% |
Attention Score in Context
This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 August 2020.
All research outputs
#6,304,537
of 23,015,156 outputs
Outputs from Translational Psychiatry
#1,680
of 3,248 outputs
Outputs of similar age
#128,377
of 443,280 outputs
Outputs of similar age from Translational Psychiatry
#39
of 84 outputs
Altmetric has tracked 23,015,156 research outputs across all sources so far. This one has received more attention than most of these and is in the 72nd percentile.
So far Altmetric has tracked 3,248 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 22.7. This one is in the 47th percentile – i.e., 47% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 443,280 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 70% of its contemporaries.
We're also able to compare this research output to 84 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 53% of its contemporaries.