| Title |
Tyrosinase inhibitors from natural and synthetic sources: structure, inhibition mechanism and perspective for the future
|
|---|---|
| Published in |
Cellular and Molecular Life Sciences, May 2005
|
| DOI | 10.1007/s00018-005-5054-y |
| Pubmed ID | |
| Authors |
Y.-J. Kim, H. Uyama |
| Abstract |
Tyrosinase is known to be a key enzyme in melanin biosynthesis, involved in determining the color of mammalian skin and hair. Various dermatological disorders, such as melasma, age spots and sites of actinic damage, arise from the accumulation of an excessive level of epidermal pigmentation. In addition, unfavorable enzymatic browning of plant-derived foods by tyrosinase causes a decrease in nutritional quality and economic loss of food products. The inadequacy of current conventional techniques to prevent tyrosinase action encourages us to seek new potent tyrosinase inhibitors. This article overviews the various inhibitors obtained from natural and synthetic sources with their industrial importance. |
Mendeley readers
The data shown below were compiled from readership statistics for 601 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Malaysia | 2 | <1% |
| Japan | 2 | <1% |
| Nepal | 1 | <1% |
| Colombia | 1 | <1% |
| Chile | 1 | <1% |
| Indonesia | 1 | <1% |
| France | 1 | <1% |
| United States | 1 | <1% |
| Unknown | 591 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 137 | 23% |
| Student > Master | 85 | 14% |
| Student > Ph. D. Student | 72 | 12% |
| Researcher | 46 | 8% |
| Student > Doctoral Student | 21 | 3% |
| Other | 93 | 15% |
| Unknown | 147 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 102 | 17% |
| Biochemistry, Genetics and Molecular Biology | 95 | 16% |
| Chemistry | 91 | 15% |
| Pharmacology, Toxicology and Pharmaceutical Science | 45 | 7% |
| Medicine and Dentistry | 33 | 5% |
| Other | 63 | 10% |
| Unknown | 172 | 29% |
Attention Score in Context
This research output has an Altmetric Attention Score of 22. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 December 2023.
All research outputs
#1,514,332
of 23,794,258 outputs
Outputs from Cellular and Molecular Life Sciences
#146
of 4,151 outputs
Outputs of similar age
#2,139
of 59,393 outputs
Outputs of similar age from Cellular and Molecular Life Sciences
#2
of 36 outputs
Altmetric has tracked 23,794,258 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 93rd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,151 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.0. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 59,393 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 96% of its contemporaries.
We're also able to compare this research output to 36 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 94% of its contemporaries.