| Title |
Promoter methylation status of hMLH1, hMSH2, and MGMT genes in colorectal cancer associated with adenoma–carcinoma sequence
|
|---|---|
| Published in |
Langenbeck's Archives of Surgery, June 2011
|
| DOI | 10.1007/s00423-011-0812-9 |
| Pubmed ID | |
| Authors |
Kyung-Hwa Lee, Ji-Shin Lee, Jong-Hee Nam, Chan Choi, Min-Cheol Lee, Chang-Soo Park, Sang-Woo Juhng, Jae-Hyuk Lee |
| Abstract |
Epigenetic silencing of the DNA mismatch repair genes has been poorly described in colorectal carcinomas showing the classic adenoma-carcinoma pathway of carcinogenesis. The aim of this study was to investigate the methylation status of MutL homolog 1 (hMLH1), MutS homolog 2 (hMSH2), and O-6-methylguanine-DNA methyltransferase (MGMT) in a series of colorectal carcinomas that contain both adenomas and carcinomas. |
Mendeley readers
The data shown below were compiled from readership statistics for 31 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | 3% |
| Denmark | 1 | 3% |
| Unknown | 29 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 5 | 16% |
| Student > Bachelor | 5 | 16% |
| Researcher | 4 | 13% |
| Student > Master | 3 | 10% |
| Student > Postgraduate | 2 | 6% |
| Other | 6 | 19% |
| Unknown | 6 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 9 | 29% |
| Biochemistry, Genetics and Molecular Biology | 7 | 23% |
| Medicine and Dentistry | 3 | 10% |
| Immunology and Microbiology | 2 | 6% |
| Environmental Science | 1 | 3% |
| Other | 3 | 10% |
| Unknown | 6 | 19% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 March 2024.
All research outputs
#7,714,942
of 23,462,326 outputs
Outputs from Langenbeck's Archives of Surgery
#275
of 1,164 outputs
Outputs of similar age
#42,375
of 116,724 outputs
Outputs of similar age from Langenbeck's Archives of Surgery
#2
of 5 outputs
Altmetric has tracked 23,462,326 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,164 research outputs from this source. They receive a mean Attention Score of 3.5. This one has gotten more attention than average, scoring higher than 61% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 116,724 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 34th percentile – i.e., 34% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 5 others from the same source and published within six weeks on either side of this one. This one has scored higher than 3 of them.