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Mapping the malaria parasite druggable genome by using in vitro evolution and chemogenomics

Overview of attention for article published in Science, January 2018
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (84th percentile)

Citations

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194 Dimensions

Readers on

mendeley
272 Mendeley
citeulike
4 CiteULike
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Title
Mapping the malaria parasite druggable genome by using in vitro evolution and chemogenomics
Published in
Science, January 2018
DOI 10.1126/science.aan4472
Pubmed ID
Authors

Annie N. Cowell, Eva S. Istvan, Amanda K. Lukens, Maria G. Gomez-Lorenzo, Manu Vanaerschot, Tomoyo Sakata-Kato, Erika L. Flannery, Pamela Magistrado, Edward Owen, Matthew Abraham, Gregory LaMonte, Heather J. Painter, Roy M. Williams, Virginia Franco, Maria Linares, Ignacio Arriaga, Selina Bopp, Victoria C. Corey, Nina F. Gnädig, Olivia Coburn-Flynn, Christin Reimer, Purva Gupta, James M. Murithi, Pedro A. Moura, Olivia Fuchs, Erika Sasaki, Sang W. Kim, Christine H. Teng, Lawrence T. Wang, Aslı Akidil, Sophie Adjalley, Paul A. Willis, Dionicio Siege, Olga Tanaseichuk, Yang Zhong, Yingyao Zhou, Manuel Llinás, Sabine Ottilie, Francisco-Javier Gamo, Marcus C. S. Lee, Daniel E. Goldberg, David A. Fidock, Dyann F. Wirth, Elizabeth A. Winzeler

Abstract

Chemogenetic characterization through in vitro evolution combined with whole-genome analysis can identify antimalarial drug targets and drug-resistance genes. We performed a genome analysis of 262 Plasmodium falciparum parasites resistant to 37 diverse compounds. We found 159 gene amplifications and 148 nonsynonymous changes in 83 genes associated with drug-resistance acquisition, where gene amplifications contributed to one-third of resistance acquisition events. Beyond confirming previously identified multidrug-resistance mechanisms, we discovered hitherto unrecognized drug target-inhibitor pairs, including thymidylate synthase and a benzoquinazolinone, farnesyltransferase and a pyrimidinedione, and a dipeptidylpeptidase and an arylurea. This exploration of the P. falciparum resistome and druggable genome will likely guide drug discovery and structural biology efforts, while also advancing our understanding of resistance mechanisms available to the malaria parasite.

X Demographics

X Demographics

The data shown below were collected from the profiles of 82 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 272 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 272 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 65 24%
Researcher 59 22%
Student > Master 26 10%
Student > Bachelor 20 7%
Professor > Associate Professor 12 4%
Other 33 12%
Unknown 57 21%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 71 26%
Agricultural and Biological Sciences 52 19%
Immunology and Microbiology 20 7%
Chemistry 15 6%
Medicine and Dentistry 14 5%
Other 34 13%
Unknown 66 24%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 208. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 January 2024.
All research outputs
#190,047
of 25,582,611 outputs
Outputs from Science
#5,542
of 83,125 outputs
Outputs of similar age
#4,322
of 452,252 outputs
Outputs of similar age from Science
#186
of 1,187 outputs
Altmetric has tracked 25,582,611 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 83,125 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 65.8. This one has done particularly well, scoring higher than 93% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 452,252 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 1,187 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 84% of its contemporaries.