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Mendeley readers
Attention Score in Context
| Title |
The RNA Component of Human Telomerase
|
|---|---|
| Published in |
Science, September 1995
|
| DOI | 10.1126/science.7544491 |
| Pubmed ID | |
| Authors |
Junli Feng, Walter D. Funk, Sy-Shi Wang, Scott L. Weinrich, Ariel A. Avilion, Choy-Pik Chiu, Robert R. Adams, Edwin Chang, Richard C. Allsopp, Jinghua Yu, Siyuan Le, Michael D. West, Calvin B. Harley, William H. Andrews,, Carol W. Greider, Bryant Villeponteau |
| Abstract |
Eukaryotic chromosomes are capped with repetitive telomere sequences that protect the ends from damage and rearrangements. Telomere repeats are synthesized by telomerase, a ribonucleic acid (RNA)-protein complex. Here, the cloning of the RNA component of human telomerase, termed hTR, is described. The template region of hTR encompasses 11 nucleotides (5'-CUAACCCUAAC) complementary to the human telomere sequence (TTAGGG)n. Germline tissues and tumor cell lines expressed more hTR than normal somatic cells and tissues, which have no detectable telomerase activity. Human cell lines that expressed hTR mutated in the template region generated the predicted mutant telomerase activity. HeLa cells transfected with an antisense hTR lost telomeric DNA and began to die after 23 to 26 doublings. Thus, human telomerase is a critical enzyme for the long-term proliferation of immortal tumor cells. |
Mendeley readers
The data shown below were compiled from readership statistics for 483 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 5 | 1% |
| India | 2 | <1% |
| Italy | 1 | <1% |
| Australia | 1 | <1% |
| United Kingdom | 1 | <1% |
| Portugal | 1 | <1% |
| Japan | 1 | <1% |
| Canada | 1 | <1% |
| Unknown | 470 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 100 | 21% |
| Student > Master | 75 | 16% |
| Student > Bachelor | 69 | 14% |
| Researcher | 49 | 10% |
| Student > Doctoral Student | 21 | 4% |
| Other | 68 | 14% |
| Unknown | 101 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 148 | 31% |
| Agricultural and Biological Sciences | 128 | 27% |
| Medicine and Dentistry | 38 | 8% |
| Chemistry | 16 | 3% |
| Immunology and Microbiology | 8 | 2% |
| Other | 33 | 7% |
| Unknown | 112 | 23% |
Attention Score in Context
This research output has an Altmetric Attention Score of 29. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 August 2023.
All research outputs
#1,164,392
of 22,893,031 outputs
Outputs from Science
#20,163
of 78,000 outputs
Outputs of similar age
#270
of 23,887 outputs
Outputs of similar age from Science
#11
of 188 outputs
Altmetric has tracked 22,893,031 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 78,000 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 62.3. This one has gotten more attention than average, scoring higher than 74% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 23,887 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 188 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 94% of its contemporaries.