| Title |
Novel biochemistry: post-translational protein splicing and other lessons from the school of antigen processing
|
|---|---|
| Published in |
Journal of Molecular Medicine, March 2005
|
| DOI | 10.1007/s00109-005-0652-6 |
| Pubmed ID | |
| Authors |
Ken-ichi Hanada, James C. Yang |
| Abstract |
In the past 15 years, the molecular identification of antigens that can mediate the killing of tumor cells by T cells has been vigorously pursued. Molecular identification of tumor-associated antigens not only provided the means to activate or monitor anti-tumor immunity, but also gave insights into new and unexpected biochemical processes that are taking place within cells. Post-translational splicing, a phenomenon previously identified only in lower organisms or plants, has recently been added to the list of atypical processes generating proteins in humans. The proteasome, whose main function is to degrade intracellular proteins, appears to catalyze this splicing reaction. The discovery of post-translational splicing has immediate and important implications for the complexity of the major histocompatibility complex (MHC) class I peptide repertoire and for the immune recognition of self- and foreign peptides. |
Mendeley readers
The data shown below were compiled from readership statistics for 21 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 1 | 5% |
| Unknown | 20 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 5 | 24% |
| Professor > Associate Professor | 4 | 19% |
| Student > Master | 3 | 14% |
| Researcher | 3 | 14% |
| Student > Bachelor | 2 | 10% |
| Other | 2 | 10% |
| Unknown | 2 | 10% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 7 | 33% |
| Biochemistry, Genetics and Molecular Biology | 5 | 24% |
| Medicine and Dentistry | 3 | 14% |
| Immunology and Microbiology | 2 | 10% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 10% |
| Other | 0 | 0% |
| Unknown | 2 | 10% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 November 2020.
All research outputs
#7,451,584
of 22,780,967 outputs
Outputs from Journal of Molecular Medicine
#504
of 1,550 outputs
Outputs of similar age
#20,690
of 59,444 outputs
Outputs of similar age from Journal of Molecular Medicine
#12
of 16 outputs
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So far Altmetric has tracked 1,550 research outputs from this source. They receive a mean Attention Score of 5.0. This one is in the 35th percentile – i.e., 35% of its peers scored the same or lower than it.
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