| Title |
Intracranial Nonthermal Irreversible Electroporation: In Vivo Analysis
|
|---|---|
| Published in |
The Journal of Membrane Biology, July 2010
|
| DOI | 10.1007/s00232-010-9284-z |
| Pubmed ID | |
| Authors |
Paulo A. Garcia, John H. Rossmeisl, Robert E. Neal, Thomas L. Ellis, John D. Olson, Natalia Henao-Guerrero, John Robertson, Rafael V. Davalos |
| Abstract |
Nonthermal irreversible electroporation (NTIRE) is a new minimally invasive technique to treat cancer. It is unique because of its nonthermal mechanism of tumor ablation. Intracranial NTIRE procedures involve placing electrodes into the targeted area of the brain and delivering a series of short but intense electric pulses. The electric pulses induce irreversible structural changes in cell membranes, leading to cell death. We correlated NTIRE lesion volumes in normal brain tissue with electric field distributions from comprehensive numerical models. The electrical conductivity of brain tissue was extrapolated from the measured in vivo data and the numerical models. Using this, we present results on the electric field threshold necessary to induce NTIRE lesions (495-510 V/cm) in canine brain tissue using 90 50-mus pulses at 4 Hz. Furthermore, this preliminary study provides some of the necessary numerical tools for using NTIRE as a brain cancer treatment. We also computed the electrical conductivity of brain tissue from the in vivo data (0.12-0.30 S/m) and provide guidelines for treatment planning and execution. Knowledge of the dynamic electrical conductivity of the tissue and electric field that correlates to lesion volume is crucial to ensure predictable complete NTIRE treatment while minimizing damage to surrounding healthy tissue. |
Mendeley readers
The data shown below were compiled from readership statistics for 105 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | <1% |
| Germany | 1 | <1% |
| Unknown | 103 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 25 | 24% |
| Researcher | 21 | 20% |
| Student > Bachelor | 12 | 11% |
| Student > Master | 9 | 9% |
| Professor > Associate Professor | 5 | 5% |
| Other | 17 | 16% |
| Unknown | 16 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Engineering | 39 | 37% |
| Medicine and Dentistry | 18 | 17% |
| Biochemistry, Genetics and Molecular Biology | 7 | 7% |
| Agricultural and Biological Sciences | 6 | 6% |
| Chemistry | 4 | 4% |
| Other | 13 | 12% |
| Unknown | 18 | 17% |
Attention Score in Context
This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 April 2024.
All research outputs
#3,463,623
of 23,806,312 outputs
Outputs from The Journal of Membrane Biology
#22
of 803 outputs
Outputs of similar age
#13,170
of 96,133 outputs
Outputs of similar age from The Journal of Membrane Biology
#1
of 11 outputs
Altmetric has tracked 23,806,312 research outputs across all sources so far. Compared to these this one has done well and is in the 84th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 803 research outputs from this source. They receive a mean Attention Score of 3.3. This one has done particularly well, scoring higher than 95% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 96,133 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 83% of its contemporaries.
We're also able to compare this research output to 11 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 90% of its contemporaries.