| Title |
Identification of GRP 78 (BiP) as a liver cell expressed receptor element for dengue virus serotype 2
|
|---|---|
| Published in |
Archives of Virology, January 2004
|
| DOI | 10.1007/s00705-003-0263-x |
| Pubmed ID | |
| Authors |
S. Jindadamrongwech, C. Thepparit, D. R. Smith |
| Abstract |
This study sought to identify receptor elements for dengue virus serotype 2 on human liver cells (HepG2) using the viral overlay protein binding assay (VOPBA) technique and Mass Spectrometry fingerprinting. A single major and several minor virus binding bands were observed, and mass spectrometry identified a candidate binding protein for the major binding band as GRP 78 (BiP). GRP78 expression on the cell surface was confirmed, and antibodies directed against both the N and C-terminus of GRP 78 (BiP) altered both the binding of the virus to the cell surface as well as the infectivity profile of HepG2 cells in response to dengue serotype 2 infection. GRP 78 (BiP), which has previously been identified as a co-receptor protein for coxsackievirus A9, is the first non-Fc receptor protein identified for the dengue virus, although GRP78 probably functions as part of a receptor complex. |
Mendeley readers
The data shown below were compiled from readership statistics for 148 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| French Polynesia | 1 | <1% |
| Germany | 1 | <1% |
| India | 1 | <1% |
| United Kingdom | 1 | <1% |
| Mexico | 1 | <1% |
| United States | 1 | <1% |
| Unknown | 142 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 36 | 24% |
| Researcher | 23 | 16% |
| Student > Master | 22 | 15% |
| Student > Bachelor | 13 | 9% |
| Professor | 7 | 5% |
| Other | 24 | 16% |
| Unknown | 23 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 42 | 28% |
| Biochemistry, Genetics and Molecular Biology | 29 | 20% |
| Medicine and Dentistry | 17 | 11% |
| Immunology and Microbiology | 13 | 9% |
| Chemistry | 6 | 4% |
| Other | 12 | 8% |
| Unknown | 29 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 April 2016.
All research outputs
#3,907,044
of 25,837,817 outputs
Outputs from Archives of Virology
#230
of 4,584 outputs
Outputs of similar age
#10,361
of 148,867 outputs
Outputs of similar age from Archives of Virology
#3
of 11 outputs
Altmetric has tracked 25,837,817 research outputs across all sources so far. Compared to these this one has done well and is in the 84th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,584 research outputs from this source. They receive a mean Attention Score of 4.0. This one has done particularly well, scoring higher than 92% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 148,867 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 90% of its contemporaries.
We're also able to compare this research output to 11 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.