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Proteases and Cancer

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Cover of 'Proteases and Cancer'

Table of Contents

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    Book Overview
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    Chapter 1 Dissecting Degradomes: Analysis of Protease-Coding Genes
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    Chapter 2 Identification of Protease Cleavage Sites and Substrates in Cancer by Carboxy-TAILS (C-TAILS)
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    Chapter 3 Identification of Proteolytic Cleavage Sites of EphA2 by Membrane Type 1 Matrix Metalloproteinase on the Surface of Cancer Cells
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    Chapter 4 Biotin-Chasing Assay to Evaluate uPAR Stability and Cleavage on the Surface of Cells
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    Chapter 5 Determination of Aconitase Activity: A Substrate of the Mitochondrial Lon Protease
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    Chapter 6 A Simple Cell-Based Assay for the Detection of Surface Protein Shedding by Rhomboid Proteases
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    Chapter 7 Functional Production of Catalytic Domains of Human MMPs in Escherichia coli Periplasm
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    Chapter 8 Autophagy and Proteases: Basic Study of the Autophagic Flux by Western Blot
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    Chapter 9 Gel-Based Gelatin Zymography to Examine Matrix Metalloproteinase Activity in Cell Culture
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    Chapter 10 Analysis of Enzymatic Activity of Matrix Metalloproteinase (MMP) by Collagen Zymography in Melanoma
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    Chapter 11 Measurement of Protease Activities Using Fluorogenic Substrates
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    Chapter 12 Targeting the Expression of Cathepsin B Using CRISPR/Cas9 System in Mammalian Cancer Cells
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    Chapter 13 Assessing the Influence of a Protease in Cell Migration Using the Barrier-Migration Assay
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    Chapter 14 Analysis of Invasive Activity of CAF Spheroids into Three Dimensional (3D) Collagen Matrices
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    Chapter 15 Beyond the Proteolytic Activity: Examining the Functional Relevance of the Ancillary Domains Using Tri-Dimensional (3D) Spheroid Invasion Assay
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    Chapter 16 Analyzing the Type II Transmembrane Serine Protease Hepsin-Dependent Basement Membrane Remodeling in 3D Cell Culture
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    Chapter 17 Evaluation of Tumor Vasculature Using a Syngeneic Tumor Model in Wild-Type and Genetically Modified Mice
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    Chapter 18 3D Image Analysis of the Microvasculature in Healthy and Diseased Tissues
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    Chapter 19 Human Tumor Tissue-Based 3D In Vitro Invasion Assays
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    Chapter 20 Ear Sponge Assay: A Method to Investigate Angiogenesis and Lymphangiogenesis in Mice
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    Chapter 21 Cancer Susceptibility Models in Protease-Deficient Mice
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    Chapter 22 Imaging Proteolytic Activities in Mouse Models of Cancer
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    Chapter 23 Protease Silencing to Explore the Molecular Mechanisms of Cancer and Aging
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    Chapter 24 Analysis of Somatic DNA Methylation Alterations of Genes Encoding Cell Surface Metallopeptidases in Colorectal Cancer
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    Chapter 25 Targeting Deubiquitinases in Cancer
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    Chapter 26 Generation of Highly Selective MMP Antibody Inhibitors
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    Chapter 27 Strategies to Target Matrix Metalloproteinases as Therapeutic Approach in Cancer
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Title
Proteases and Cancer
Published by
Humana Press, New York, NY, February 2018
DOI 10.1007/978-1-4939-7595-2
ISBNs
978-1-4939-7594-5, 978-1-4939-7595-2
Editors

Santiago Cal, Alvaro J. Obaya

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