| Title |
SVCT1 and SVCT2: key proteins for vitamin C uptake
|
|---|---|
| Published in |
Amino Acids, June 2007
|
| DOI | 10.1007/s00726-007-0555-7 |
| Pubmed ID | |
| Authors |
I. Savini, A. Rossi, C. Pierro, L. Avigliano, M. V. Catani |
| Abstract |
Vitamin C is accumulated in mammalian cells by two types of proteins: sodium-ascorbate co-transporters (SVCTs) and hexose transporters (GLUTs); in particular, SVCTs actively import ascorbate, the reduced form of this vitamin. SVCTs are surface glycoproteins encoded by two different genes, very similar in structure. They show distinct tissue distribution and functional characteristics, which indicate different physiological roles. SVCT1 is involved in whole-body homeostasis of vitamin C, while SVCT2 protects metabolically active cells against oxidative stress. Regulation at mRNA or protein level may serve for preferential accumulation of ascorbic acid at sites where it is needed. This review will summarize the present knowledge on structure, function and regulation of the SVCT transporters. Understanding the physiological role of SVCT1 and SVCT2 may lead to develop new therapeutic strategies to control intracellular vitamin C content or to promote tissue-specific delivery of vitamin C-drug conjugates. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Practitioners (doctors, other healthcare professionals) | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 257 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | <1% |
| Portugal | 1 | <1% |
| Norway | 1 | <1% |
| Hungary | 1 | <1% |
| Italy | 1 | <1% |
| Egypt | 1 | <1% |
| Denmark | 1 | <1% |
| Jordan | 1 | <1% |
| Unknown | 248 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 40 | 16% |
| Student > Ph. D. Student | 39 | 15% |
| Researcher | 35 | 14% |
| Student > Master | 32 | 12% |
| Professor > Associate Professor | 12 | 5% |
| Other | 40 | 16% |
| Unknown | 59 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 60 | 23% |
| Biochemistry, Genetics and Molecular Biology | 48 | 19% |
| Medicine and Dentistry | 37 | 14% |
| Pharmacology, Toxicology and Pharmaceutical Science | 11 | 4% |
| Chemistry | 9 | 4% |
| Other | 27 | 11% |
| Unknown | 65 | 25% |
Attention Score in Context
This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 April 2023.
All research outputs
#5,451,316
of 25,773,273 outputs
Outputs from Amino Acids
#314
of 1,619 outputs
Outputs of similar age
#15,937
of 83,741 outputs
Outputs of similar age from Amino Acids
#2
of 14 outputs
Altmetric has tracked 25,773,273 research outputs across all sources so far. Compared to these this one has done well and is in the 78th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,619 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.8. This one has done well, scoring higher than 80% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 83,741 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 80% of its contemporaries.
We're also able to compare this research output to 14 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 85% of its contemporaries.