↓ Skip to main content

Extracellular DNA traps promote thrombosis

Overview of attention for article published in Proceedings of the National Academy of Sciences of the United States of America, August 2010
Altmetric Badge

About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (98th percentile)
  • High Attention Score compared to outputs of the same age and source (94th percentile)

Mentioned by

news
5 news outlets
blogs
1 blog
twitter
2 X users
patent
42 patents
wikipedia
15 Wikipedia pages

Citations

dimensions_citation
1920 Dimensions

Readers on

mendeley
1051 Mendeley
citeulike
2 CiteULike
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
Extracellular DNA traps promote thrombosis
Published in
Proceedings of the National Academy of Sciences of the United States of America, August 2010
DOI 10.1073/pnas.1005743107
Pubmed ID
Authors

Tobias A. Fuchs, Alexander Brill, Daniel Duerschmied, Daphne Schatzberg, Marc Monestier, Daniel D. Myers, Shirley K. Wrobleski, Thomas W. Wakefield, John H. Hartwig, Denisa D. Wagner

Abstract

Neutrophil extracellular traps (NETs) are part of the innate immune response to infections. NETs are a meshwork of DNA fibers comprising histones and antimicrobial proteins. Microbes are immobilized in NETs and encounter a locally high and lethal concentration of effector proteins. Recent studies show that NETs are formed inside the vasculature in infections and noninfectious diseases. Here we report that NETs provide a heretofore unrecognized scaffold and stimulus for thrombus formation. NETs perfused with blood caused platelet adhesion, activation, and aggregation. DNase or the anticoagulant heparin dismantled the NET scaffold and prevented thrombus formation. Stimulation of platelets with purified histones was sufficient for aggregation. NETs recruited red blood cells, promoted fibrin deposition, and induced a red thrombus, such as that found in veins. Markers of extracellular DNA traps were detected in a thrombus and plasma of baboons subjected to deep vein thrombosis, an example of inflammation-enhanced thrombosis. Our observations indicate that NETs are a previously unrecognized link between inflammation and thrombosis and may further explain the epidemiological association of infection with thrombosis.

X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 1,051 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Netherlands 3 <1%
United States 3 <1%
Poland 2 <1%
Austria 1 <1%
Sweden 1 <1%
United Kingdom 1 <1%
Colombia 1 <1%
Belgium 1 <1%
Germany 1 <1%
Other 2 <1%
Unknown 1035 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 183 17%
Researcher 135 13%
Student > Bachelor 120 11%
Student > Master 110 10%
Student > Doctoral Student 81 8%
Other 161 15%
Unknown 261 25%
Readers by discipline Count As %
Medicine and Dentistry 249 24%
Agricultural and Biological Sciences 168 16%
Biochemistry, Genetics and Molecular Biology 140 13%
Immunology and Microbiology 92 9%
Pharmacology, Toxicology and Pharmaceutical Science 22 2%
Other 78 7%
Unknown 302 29%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 66. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 February 2024.
All research outputs
#621,055
of 24,625,114 outputs
Outputs from Proceedings of the National Academy of Sciences of the United States of America
#10,701
of 101,438 outputs
Outputs of similar age
#1,549
of 99,246 outputs
Outputs of similar age from Proceedings of the National Academy of Sciences of the United States of America
#37
of 660 outputs
Altmetric has tracked 24,625,114 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 101,438 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 38.8. This one has done well, scoring higher than 89% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 99,246 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 660 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 94% of its contemporaries.