| Title |
Ki-67: more than a proliferation marker
|
|---|---|
| Published in |
Chromosoma, January 2018
|
| DOI | 10.1007/s00412-018-0659-8 |
| Pubmed ID | |
| Authors |
Xiaoming Sun, Paul D. Kaufman |
| Abstract |
Ki-67 protein has been widely used as a proliferation marker for human tumor cells for decades. In recent studies, multiple molecular functions of this large protein have become better understood. Ki-67 has roles in both interphase and mitotic cells, and its cellular distribution dramatically changes during cell cycle progression. These localizations correlate with distinct functions. For example, during interphase, Ki-67 is required for normal cellular distribution of heterochromatin antigens and for the nucleolar association of heterochromatin. During mitosis, Ki-67 is essential for formation of the perichromosomal layer (PCL), a ribonucleoprotein sheath coating the condensed chromosomes. In this structure, Ki-67 acts to prevent aggregation of mitotic chromosomes. Here, we present an overview of functional roles of Ki-67 across the cell cycle and also describe recent experiments that clarify its role in regulating cell cycle progression in human cells. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 50% |
| India | 1 | 25% |
| Unknown | 1 | 25% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Practitioners (doctors, other healthcare professionals) | 3 | 75% |
| Members of the public | 1 | 25% |
Mendeley readers
The data shown below were compiled from readership statistics for 882 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 882 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 164 | 19% |
| Student > Ph. D. Student | 120 | 14% |
| Student > Master | 108 | 12% |
| Researcher | 65 | 7% |
| Student > Doctoral Student | 41 | 5% |
| Other | 86 | 10% |
| Unknown | 298 | 34% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 238 | 27% |
| Medicine and Dentistry | 113 | 13% |
| Agricultural and Biological Sciences | 69 | 8% |
| Pharmacology, Toxicology and Pharmaceutical Science | 26 | 3% |
| Immunology and Microbiology | 25 | 3% |
| Other | 95 | 11% |
| Unknown | 316 | 36% |
Attention Score in Context
This research output has an Altmetric Attention Score of 12. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 November 2023.
All research outputs
#2,880,848
of 24,770,025 outputs
Outputs from Chromosoma
#31
of 788 outputs
Outputs of similar age
#63,083
of 454,285 outputs
Outputs of similar age from Chromosoma
#4
of 12 outputs
Altmetric has tracked 24,770,025 research outputs across all sources so far. Compared to these this one has done well and is in the 88th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 788 research outputs from this source. They receive a mean Attention Score of 3.8. This one has done particularly well, scoring higher than 96% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 454,285 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 86% of its contemporaries.
We're also able to compare this research output to 12 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 75% of its contemporaries.