Title |
Necessity of Quantum Coherence to Account for the Spectrum of Time-Dependent Mutations Exhibited by Bacteriophage T4
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Published in |
Biochemical Genetics, October 2009
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DOI | 10.1007/s10528-009-9293-8 |
Pubmed ID | |
Authors |
W. Grant Cooper |
Abstract |
Transcriptase measurements of quantum expectations due to time-dependent coherent states populating informational DNA base-pair sites, designated by G-C --> *G-*C, G-C --> G'-C', and A-T --> *A-*T, provide a model for transcription and replication of time-dependent DNA lesions exhibited by bacteriophage T4. Coherent states are introduced as consequences of hydrogen bond arrangement, keto-amino --> enol-imine, where product protons are shared between two sets of indistinguishable electron lone-pairs and thus participate in coupled quantum oscillations at frequencies of ~10(13) s(-1). The transcriptase deciphers and executes genetic specificity instructions by implementing measurements on superposition proton states at *G-*C, G'-C', and *A-*T sites in an interval Δt < 10(-13) s. Decohered states participate in Topal-Fresco replication, which introduces substitutions *C --> T, *G --> A, G' --> T, and G' --> C, but superposition *A-*T states are deleted. These results imply an evolutionary shift favoring A-T richness. |
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