| Title |
SET domain proteins modulate chromatin domains in eu- and heterochromatin
|
|---|---|
| Published in |
Cellular and Molecular Life Sciences, January 1998
|
| DOI | 10.1007/s000180050127 |
| Pubmed ID | |
| Authors |
T. Jenuwein, G. Laible, R. Dorn, G. Reuter |
| Abstract |
The SET domain is a 130-amino acid, evolutionarily conserved sequence motif present in chromosomal proteins that function in modulating gene activities from yeast to mammals. Initially identified as members of the Polycomb- and trithorax-group (Pc-G and trx-G) gene families, which are required to maintain expression boundaries of homeotic selector (HOM-C) genes, SET domain proteins are also involved in position-effect-variegation (PEV), telomeric and centromeric gene silencing, and possibly in determining chromosome architecture. These observations implicate SET domain proteins as multifunctional chromatin regulators with activities in both eu- and heterochromatin--a role consistent with their modular structure, which combines the SET domain with additional sequence motifs of either a cysteine-rich region/zinc-finger type or the chromo domain. Multiple functions for chromatin regulators are not restricted to the SET protein family, since many trx-G (but only very few Pc-G) genes are also modifiers of PEV. Together, these data establish a model in which the modulation of chromatin domains is mechanistically linked with the regulation of key developmental loci (e.g. HOM-C). |
Mendeley readers
The data shown below were compiled from readership statistics for 250 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | <1% |
| Hungary | 1 | <1% |
| Netherlands | 1 | <1% |
| Australia | 1 | <1% |
| France | 1 | <1% |
| Canada | 1 | <1% |
| Mexico | 1 | <1% |
| Japan | 1 | <1% |
| United States | 1 | <1% |
| Other | 1 | <1% |
| Unknown | 239 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 84 | 34% |
| Researcher | 38 | 15% |
| Student > Master | 26 | 10% |
| Student > Bachelor | 20 | 8% |
| Student > Doctoral Student | 12 | 5% |
| Other | 37 | 15% |
| Unknown | 33 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 94 | 38% |
| Biochemistry, Genetics and Molecular Biology | 75 | 30% |
| Medicine and Dentistry | 12 | 5% |
| Immunology and Microbiology | 6 | 2% |
| Chemistry | 6 | 2% |
| Other | 18 | 7% |
| Unknown | 39 | 16% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 May 2017.
All research outputs
#5,431,319
of 25,388,229 outputs
Outputs from Cellular and Molecular Life Sciences
#1,167
of 5,783 outputs
Outputs of similar age
#8,251
of 95,402 outputs
Outputs of similar age from Cellular and Molecular Life Sciences
#4
of 14 outputs
Altmetric has tracked 25,388,229 research outputs across all sources so far. Compared to these this one has done well and is in the 75th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,783 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.8. This one has gotten more attention than average, scoring higher than 72% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 95,402 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 85% of its contemporaries.
We're also able to compare this research output to 14 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 71% of its contemporaries.