| Title |
Evaluation of the iron regulatory protein-1 interactome
|
|---|---|
| Published in |
BioMetals, January 2018
|
| DOI | 10.1007/s10534-018-0076-8 |
| Pubmed ID | |
| Authors |
Gregory J. Connell, Jando S. Danial, Christian X. Haastruthers |
| Abstract |
The interactions of iron regulatory proteins (IRPs) with mRNAs containing an iron-responsive element (IRE) is a major means through which intracellular iron homeostasis is maintained and integrated with cellular function. Although IRE-IRP interactions have been proposed to modulate the expression of a diverse number of mRNAs, a transcriptome analysis of the interactions that form within the native mRNA structure and cellular environment has not previously been described. An RNA-CLIP study is described here that identified IRP-1 interactions occurring within a primary cell line expressing physiologically relevant amounts of mRNA and protein. The study suggests that only a small subset of the previously proposed IREs interact with IRP-1 in situ. Identifying authentic IRP interactions is not only important to a greater understanding of iron homeostasis and its integration with cell biology but also to the development of novel therapeutics that can compensate for iron imbalances. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 18 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 18 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 4 | 22% |
| Student > Bachelor | 2 | 11% |
| Other | 2 | 11% |
| Student > Ph. D. Student | 2 | 11% |
| Student > Doctoral Student | 1 | 6% |
| Other | 3 | 17% |
| Unknown | 4 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 4 | 22% |
| Agricultural and Biological Sciences | 2 | 11% |
| Computer Science | 2 | 11% |
| Medicine and Dentistry | 2 | 11% |
| Chemistry | 2 | 11% |
| Other | 2 | 11% |
| Unknown | 4 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 October 2018.
All research outputs
#7,296,667
of 23,016,919 outputs
Outputs from BioMetals
#146
of 647 outputs
Outputs of similar age
#148,942
of 443,072 outputs
Outputs of similar age from BioMetals
#3
of 12 outputs
Altmetric has tracked 23,016,919 research outputs across all sources so far. This one has received more attention than most of these and is in the 67th percentile.
So far Altmetric has tracked 647 research outputs from this source. They receive a mean Attention Score of 4.3. This one has done well, scoring higher than 75% of its peers.
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We're also able to compare this research output to 12 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 75% of its contemporaries.