| Title |
Coffee with a high content of chlorogenic acids and low content of hydroxyhydroquinone improves postprandial endothelial dysfunction in patients with borderline and stage 1 hypertension
|
|---|---|
| Published in |
European Journal of Nutrition, January 2018
|
| DOI | 10.1007/s00394-018-1611-7 |
| Pubmed ID | |
| Authors |
Masato Kajikawa, Tatsuya Maruhashi, Takayuki Hidaka, Yukiko Nakano, Satoshi Kurisu, Takeshi Matsumoto, Yumiko Iwamoto, Shinji Kishimoto, Shogo Matsui, Yoshiki Aibara, Farina Mohamad Yusoff, Yasuki Kihara, Kazuaki Chayama, Chikara Goto, Kensuke Noma, Ayumu Nakashima, Takuya Watanabe, Hiroshi Tone, Masanobu Hibi, Noriko Osaki, Yoshihisa Katsuragi, Yukihito Higashi |
| Abstract |
The purpose of this study was to evaluate acute effects of coffee with a high content of chlorogenic acids and different hydroxyhydroquinone contents on postprandial endothelial dysfunction. This was a single-blind, randomized, placebo-controlled, crossover-within-subject clinical trial. A total of 37 patients with borderline or stage 1 hypertension were randomized to two study groups. The participants consumed a test meal with a single intake of the test coffee. Subjects in the Study 1 group were randomized to single intake of coffee with a high content of chlorogenic acids and low content of hydroxyhydroquinone or coffee with a high content of chlorogenic acids and a high content of hydroxyhydroquinone with crossover. Subjects in the Study 2 group were randomized to single intake of coffee with a high content of chlorogenic acids and low content of hydroxyhydroquinone or placebo coffee with crossover. Endothelial function assessed by flow-mediated vasodilation and plasma concentration of 8-isoprostanes were measured at baseline and at 1 and 2 h after coffee intake. Compared with baseline values, single intake of coffee with a high content of chlorogenic acids and low content of hydroxyhydroquinone, but not coffee with a high content of chlorogenic acids and high content of hydroxyhydroquinone or placebo coffee, significantly improved postprandial flow-mediated vasodilation and decreased circulating 8-isoprostane levels. These findings suggest that a single intake of coffee with a high content of chlorogenic acids and low content of hydroxyhydroquinone is effective for improving postprandial endothelial dysfunction. URL for Clinical Trial: https://upload.umin.ac.jp ; Registration Number for Clinical Trial: UMIN000013283. |
X Demographics
The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 40% |
| Japan | 1 | 20% |
| Norway | 1 | 20% |
| Ireland | 1 | 20% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 60% |
| Scientists | 2 | 40% |
Mendeley readers
The data shown below were compiled from readership statistics for 68 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 68 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 7 | 10% |
| Researcher | 6 | 9% |
| Lecturer | 6 | 9% |
| Student > Bachelor | 6 | 9% |
| Student > Master | 5 | 7% |
| Other | 16 | 24% |
| Unknown | 22 | 32% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 19 | 28% |
| Nursing and Health Professions | 6 | 9% |
| Biochemistry, Genetics and Molecular Biology | 4 | 6% |
| Chemistry | 3 | 4% |
| Agricultural and Biological Sciences | 3 | 4% |
| Other | 6 | 9% |
| Unknown | 27 | 40% |
Attention Score in Context
This research output has an Altmetric Attention Score of 247. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 December 2023.
All research outputs
#146,141
of 24,955,994 outputs
Outputs from European Journal of Nutrition
#48
of 2,556 outputs
Outputs of similar age
#3,464
of 455,250 outputs
Outputs of similar age from European Journal of Nutrition
#4
of 46 outputs
Altmetric has tracked 24,955,994 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,556 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 25.5. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 455,250 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 46 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 93% of its contemporaries.