| Title |
Extracellular matrix molecules and their potential contribution to the function of transplanted pancreatic islets
|
|---|---|
| Published in |
Diabetologia, January 2018
|
| DOI | 10.1007/s00125-017-4524-8 |
| Pubmed ID | |
| Authors |
L. Alberto Llacua, Marijke M. Faas, Paul de Vos |
| Abstract |
Extracellular matrix (ECM) molecules are responsible for structural and biochemical support, as well as for regulation of molecular signalling and tissue repair in many organ structures, including the pancreas. In pancreatic islets, collagen type IV and VI, and laminins are the most abundant molecules, but other ECM molecules are also present. The ECM interacts with specific combinations of integrin α/β heterodimers on islet cells and guides many cellular processes. More specifically, some ECM molecules are involved in beta cell survival, function and insulin production, while others can fine tune the susceptibility of islet cells to cytokines. Further, some ECM induce release of growth factors to facilitate tissue repair. During enzymatic isolation of islets for transplantation, the ECM is damaged, impacting islet function. However, restoration of the ECM in human islets (for example by adding ECM to the interior of immunoprotective capsules) has been shown to enhance islet function. Here, we provide current insight into the role of ECM molecules in islet function and discuss the clinical potential of ECM manipulation to enhance pancreatic islet function and survival. |
X Demographics
The data shown below were collected from the profiles of 15 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 5 | 33% |
| Germany | 2 | 13% |
| United States | 1 | 7% |
| Switzerland | 1 | 7% |
| Unknown | 6 | 40% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 9 | 60% |
| Scientists | 3 | 20% |
| Practitioners (doctors, other healthcare professionals) | 2 | 13% |
| Science communicators (journalists, bloggers, editors) | 1 | 7% |
Mendeley readers
The data shown below were compiled from readership statistics for 165 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 165 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 39 | 24% |
| Researcher | 22 | 13% |
| Student > Master | 20 | 12% |
| Student > Bachelor | 18 | 11% |
| Student > Doctoral Student | 9 | 5% |
| Other | 12 | 7% |
| Unknown | 45 | 27% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 47 | 28% |
| Engineering | 21 | 13% |
| Agricultural and Biological Sciences | 13 | 8% |
| Medicine and Dentistry | 12 | 7% |
| Chemistry | 4 | 2% |
| Other | 15 | 9% |
| Unknown | 53 | 32% |
Attention Score in Context
This research output has an Altmetric Attention Score of 11. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 January 2023.
All research outputs
#3,196,633
of 25,109,675 outputs
Outputs from Diabetologia
#1,543
of 5,316 outputs
Outputs of similar age
#68,552
of 454,735 outputs
Outputs of similar age from Diabetologia
#39
of 61 outputs
Altmetric has tracked 25,109,675 research outputs across all sources so far. Compared to these this one has done well and is in the 87th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,316 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 24.6. This one has gotten more attention than average, scoring higher than 70% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 454,735 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 84% of its contemporaries.
We're also able to compare this research output to 61 others from the same source and published within six weeks on either side of this one. This one is in the 37th percentile – i.e., 37% of its contemporaries scored the same or lower than it.