Title |
ACTH protects against glucocorticoid-induced osteonecrosis of bone
|
---|---|
Published in |
Proceedings of the National Academy of Sciences of the United States of America, April 2010
|
DOI | 10.1073/pnas.0912176107 |
Pubmed ID | |
Authors |
Mone Zaidi, Li Sun, Lisa J. Robinson, Irina L. Tourkova, Li Liu, Yujuan Wang, Ling-Ling Zhu, Xuan Liu, Jianhua Li, Yuanzhen Peng, Guozhe Yang, Xingming Shi, Alice Levine, Jameel Iqbal, Beatrice B. Yaroslavskiy, Carlos Isales, Harry C. Blair |
Abstract |
We report that adrenocorticotropic hormone (ACTH) protects against osteonecrosis of the femoral head induced by depot methylprednisolone acetate (depomedrol). This therapeutic response likely arises from enhanced osteoblastic support and the stimulation of VEGF by ACTH; the latter is largely responsible for maintaining the fine vascular network that surrounds highly remodeling bone. We suggest examining the efficacy of ACTH in preventing human osteonecrosis, a devastating complication of glucocorticoid therapy. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 3% |
Mexico | 1 | 2% |
Germany | 1 | 2% |
Norway | 1 | 2% |
Unknown | 60 | 92% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 11 | 17% |
Other | 8 | 12% |
Student > Ph. D. Student | 6 | 9% |
Student > Doctoral Student | 5 | 8% |
Student > Bachelor | 5 | 8% |
Other | 16 | 25% |
Unknown | 14 | 22% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 22 | 34% |
Agricultural and Biological Sciences | 14 | 22% |
Biochemistry, Genetics and Molecular Biology | 4 | 6% |
Unspecified | 3 | 5% |
Social Sciences | 2 | 3% |
Other | 3 | 5% |
Unknown | 17 | 26% |