| Title |
Structural insights into the function of Elongator
|
|---|---|
| Published in |
Cellular and Molecular Life Sciences, January 2018
|
| DOI | 10.1007/s00018-018-2747-6 |
| Pubmed ID | |
| Authors |
Udit Dalwadi, Calvin K. Yip |
| Abstract |
Conserved from yeast to humans, Elongator is a protein complex implicated in multiple processes including transcription regulation, α-tubulin acetylation, and tRNA modification, and its defects have been shown to cause human diseases such as familial dysautonomia. Elongator consists of two copies of six core subunits (Elp1, Elp2, Elp3, Elp4, Elp5, and Elp6) that are organized into two subcomplexes: Elp1/2/3 and Elp4/5/6 and form a stable assembly of ~ 850 kDa in size. Although the catalytic subunit of Elongator is Elp3, which contains a radical S-adenosyl-L-methionine (SAM) domain and a putative histone acetyltransferase domain, the Elp4/5/6 subcomplex also possesses ATP-modulated tRNA binding activity. How at the molecular level, Elongator performs its multiple functions and how the different subunits regulate Elongator's activities remains poorly understood. Here, we provide an overview of the proposed functions of Elongator and describe how recent structural studies provide new insights into the mechanism of action of this multifunctional complex. |
X Demographics
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| France | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 54 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 54 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 17 | 31% |
| Student > Bachelor | 8 | 15% |
| Researcher | 6 | 11% |
| Student > Master | 6 | 11% |
| Student > Doctoral Student | 3 | 6% |
| Other | 4 | 7% |
| Unknown | 10 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 20 | 37% |
| Agricultural and Biological Sciences | 10 | 19% |
| Neuroscience | 4 | 7% |
| Chemistry | 3 | 6% |
| Medicine and Dentistry | 3 | 6% |
| Other | 3 | 6% |
| Unknown | 11 | 20% |
Attention Score in Context
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#21,141,111
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Outputs from Cellular and Molecular Life Sciences
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Outputs of similar age from Cellular and Molecular Life Sciences
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