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Human cytomegalovirus: clinical aspects, immune regulation, and emerging treatments

Overview of attention for article published in Lancet Infectious Diseases, December 2004
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Mentioned by

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1 patent

Citations

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465 Dimensions

Readers on

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385 Mendeley
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2 CiteULike
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Title
Human cytomegalovirus: clinical aspects, immune regulation, and emerging treatments
Published in
Lancet Infectious Diseases, December 2004
DOI 10.1016/s1473-3099(04)01202-2
Pubmed ID
Authors

Maher K Gandhi, Rajiv Khanna

Abstract

After initial infection, human cytomegalovirus remains in a persistent state with the host. Immunity against the virus controls replication, although intermitent viral shedding can still take place in the seropositive immunocompetent person. Replication of cytomegalovirus in the absence of an effective immune response is central to the pathogenesis of disease. Therefore, complications are primarily seen in individuals whose immune system is immature, or is suppressed by drug treatment or coinfection with other pathogens. Although our increasing knowledge of the host-virus relationship has lead to the development of new pharmacological strategies for cytomegalovirus-associated infections, these strategies all have limitations-eg, drug toxicities, development of resistance, poor oral bioavailability, and low potency. Immune-based therapies to complement pharmacological strategies for the successful treatment of virus-associated complications should be prospectively investigated.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 385 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 2 <1%
Belgium 2 <1%
Netherlands 1 <1%
Ecuador 1 <1%
Malaysia 1 <1%
Czechia 1 <1%
United Kingdom 1 <1%
Peru 1 <1%
Brazil 1 <1%
Other 4 1%
Unknown 370 96%

Demographic breakdown

Readers by professional status Count As %
Student > Master 73 19%
Student > Bachelor 73 19%
Student > Ph. D. Student 47 12%
Researcher 39 10%
Student > Postgraduate 29 8%
Other 67 17%
Unknown 57 15%
Readers by discipline Count As %
Medicine and Dentistry 149 39%
Agricultural and Biological Sciences 62 16%
Biochemistry, Genetics and Molecular Biology 40 10%
Immunology and Microbiology 33 9%
Pharmacology, Toxicology and Pharmaceutical Science 17 4%
Other 22 6%
Unknown 62 16%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 January 2020.
All research outputs
#8,534,976
of 25,374,647 outputs
Outputs from Lancet Infectious Diseases
#4,242
of 6,038 outputs
Outputs of similar age
#38,953
of 151,956 outputs
Outputs of similar age from Lancet Infectious Diseases
#11
of 18 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 6,038 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 92.3. This one is in the 25th percentile – i.e., 25% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 151,956 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 16th percentile – i.e., 16% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 18 others from the same source and published within six weeks on either side of this one. This one is in the 11th percentile – i.e., 11% of its contemporaries scored the same or lower than it.