Title |
Human cytomegalovirus: clinical aspects, immune regulation, and emerging treatments
|
---|---|
Published in |
Lancet Infectious Diseases, December 2004
|
DOI | 10.1016/s1473-3099(04)01202-2 |
Pubmed ID | |
Authors |
Maher K Gandhi, Rajiv Khanna |
Abstract |
After initial infection, human cytomegalovirus remains in a persistent state with the host. Immunity against the virus controls replication, although intermitent viral shedding can still take place in the seropositive immunocompetent person. Replication of cytomegalovirus in the absence of an effective immune response is central to the pathogenesis of disease. Therefore, complications are primarily seen in individuals whose immune system is immature, or is suppressed by drug treatment or coinfection with other pathogens. Although our increasing knowledge of the host-virus relationship has lead to the development of new pharmacological strategies for cytomegalovirus-associated infections, these strategies all have limitations-eg, drug toxicities, development of resistance, poor oral bioavailability, and low potency. Immune-based therapies to complement pharmacological strategies for the successful treatment of virus-associated complications should be prospectively investigated. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Germany | 2 | <1% |
Belgium | 2 | <1% |
Netherlands | 1 | <1% |
Ecuador | 1 | <1% |
Malaysia | 1 | <1% |
Czechia | 1 | <1% |
United Kingdom | 1 | <1% |
Peru | 1 | <1% |
Brazil | 1 | <1% |
Other | 4 | 1% |
Unknown | 370 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 73 | 19% |
Student > Bachelor | 73 | 19% |
Student > Ph. D. Student | 47 | 12% |
Researcher | 39 | 10% |
Student > Postgraduate | 29 | 8% |
Other | 67 | 17% |
Unknown | 57 | 15% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 149 | 39% |
Agricultural and Biological Sciences | 62 | 16% |
Biochemistry, Genetics and Molecular Biology | 40 | 10% |
Immunology and Microbiology | 33 | 9% |
Pharmacology, Toxicology and Pharmaceutical Science | 17 | 4% |
Other | 22 | 6% |
Unknown | 62 | 16% |