| Title |
Lactoferrin modulation of IL-12 and IL-10 response from activated murine leukocytes
|
|---|---|
| Published in |
Medical Microbiology and Immunology, March 2007
|
| DOI | 10.1007/s00430-007-0041-6 |
| Pubmed ID | |
| Authors |
Shen-An Hwang, Katarzyna M. Wilk, Yogesh A. Bangale, Marian L. Kruzel, Jeffrey K. Actor |
| Abstract |
Lactoferrin possesses a wide range of immunomodulatory activities, including promotion of the delayed type hypersensitivity response (DTH) towards BCG (Bacillus Calmette Guerin) antigens. Addition of Lactoferrin as an adjuvant to the BCG vaccine was previously demonstrated to augment protection against subsequent mycobacterial challenge, with concomitant development of a strong T cell helper type 1 (TH1) immunity. Because generation of TH1 immunity is in large part dependent on the balance of monocytic pro- and anti-inflammatory cytokines, the effect of Lactoferrin on leukocytes was investigated. Lactoferrin enhanced proinflammatory responses in a dose-dependant manner from splenocyte and adherent (F4/80+) splenocyte populations, bone marrow derived monocytes (BMM), and J774A.1 cultured cells. In all scenarios tested, Lactoferrin induced a strong increase in the ratio of IL-12:IL-10 production from LPS stimulated cells. Examination of Lactoferrin effects on BCG infected J774A.1 cells and on BMM revealed similar immunomodulatory effects, with particularly strong increase in IL-12 production. Furthermore, immunization of mice with BCG admixed with Lactoferrin led to increased generation of CD4+ cells expressing IFN-gamma upon restimulation with BCG antigens. These results provide molecular evidence to support the role of Lactoferrin as an adjuvant candidate to augment development of DTH response to vaccine antigens. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 1 | 50% |
| Canada | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 38 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 38 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 7 | 18% |
| Other | 3 | 8% |
| Student > Ph. D. Student | 3 | 8% |
| Professor > Associate Professor | 3 | 8% |
| Professor | 2 | 5% |
| Other | 9 | 24% |
| Unknown | 11 | 29% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 6 | 16% |
| Medicine and Dentistry | 6 | 16% |
| Immunology and Microbiology | 6 | 16% |
| Biochemistry, Genetics and Molecular Biology | 5 | 13% |
| Social Sciences | 2 | 5% |
| Other | 1 | 3% |
| Unknown | 12 | 32% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 November 2021.
All research outputs
#14,599,162
of 23,815,455 outputs
Outputs from Medical Microbiology and Immunology
#400
of 627 outputs
Outputs of similar age
#67,327
of 78,304 outputs
Outputs of similar age from Medical Microbiology and Immunology
#5
of 5 outputs
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