Title |
A Case of Daptomycin-induced Eosinophilic Pneumonia and a Review of the Published Literature
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Published in |
Internal Medicine, November 2017
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DOI | 10.2169/internalmedicine.9010-17 |
Pubmed ID | |
Authors |
Yoshitsugu Higashi, Shigeki Nakamura, Yasuhiro Tsuji, Chika Ogami, Kaoru Matsumoto, Koyomi Kawago, Kotaro Tokui, Ryuji Hayashi, Ippei Sakamaki, Yoshihiro Yamamoto |
Abstract |
A 53-year-old man was admitted to the hospital with a diagnosis of cellulitis and osteomyelitis. Twenty-four days after the initiation of daptomycin and sulbactam/ampicillin, he developed a fever and pulmonary infiltration. Bronchoalveolar lavage revealed a high number of eosinophils, while an intracutaneous test revealed positivity for daptomycin. The patient improved after discontinuing antimicrobial therapy. The plasma daptomycin minimum concentration (Cmin) was elevated (27.4 μg/mL), but plasma protein binding of daptomycin was low (87.8%). Although the pathophysiology of eosinophilic pneumonia remains unclear, antigenic stimulation due to daptomycin accumulation in the alveoli may have caused continuous immune activation. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 3 | 60% |
Japan | 1 | 20% |
Unknown | 1 | 20% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 3 | 60% |
Science communicators (journalists, bloggers, editors) | 1 | 20% |
Practitioners (doctors, other healthcare professionals) | 1 | 20% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 40 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Other | 7 | 18% |
Student > Bachelor | 6 | 15% |
Lecturer | 4 | 10% |
Student > Postgraduate | 3 | 8% |
Student > Doctoral Student | 2 | 5% |
Other | 6 | 15% |
Unknown | 12 | 30% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 17 | 43% |
Nursing and Health Professions | 3 | 8% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 8% |
Biochemistry, Genetics and Molecular Biology | 2 | 5% |
Agricultural and Biological Sciences | 1 | 3% |
Other | 4 | 10% |
Unknown | 10 | 25% |