Title |
Transcatheter Aortic Valve Implantation (TAVI) for Native Aortic Valve Regurgitation ― A Systematic Review ―
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Published in |
Circulation Journal, December 2017
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DOI | 10.1253/circj.cj-17-0672 |
Pubmed ID | |
Authors |
Altayyeb Yousef, Zachary MacDonald, Trevor Simard, Juan J Russo, Joshua Feder, Michael V Froeschl, Alexander Dick, Christopher Glover, Ian G Burwash, Azeem Latib, Josep Rodés-Cabau, Marino Labinaz, Benjamin Hibbert |
Abstract |
Transcatheter aortic valve implantation (TAVI) has become the standard of care for management of high-risk patients with aortic stenosis. Limited data is available regarding the performance of TAVI in patients with native aortic valve regurgitation (NAVR).Methods and Results:We performed a systematic review from 2002 to 2016. The primary outcome was device success as per VARC-2 criteria. Secondary endpoints included procedural complications, and 30-day and 1-year mortality rates. A total of 175 patients were included from 31 studies. Device success was reported in 86.3% of patients - with device failure driven by moderate aortic regurgitation (AR ≥3+) and/or need for a second device. Procedural complications were rare, with no procedural deaths, myocardial infarctions or annular ruptures reported. Procedural safety was acceptable with a low 30-day incidence of stroke (1.5%). The 30-day and 1-year overall mortality rates were 9.6% and 20.0% (cardiovascular death, 3.8% and 10.1%, respectively). Patients receiving 2nd-generation valves demonstrated similar safety profiles with greater device success compared with 1st-generation valves (96.2% vs. 78.4%). This was driven by the higher incidence of second-valve implantation (23.4% vs. 1.7%) and significant paravalvular leak (8.3% vs. 0.0%). TAVI demonstrates acceptable safety and efficacy in high-risk patients with severe NAVR. Second-generation valves may afford a similar safety profile with improved device success. Dedicated studies are needed to definitively establish the efficacy of TAVI in this population. |
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Kuwait | 3 | 60% |
United States | 2 | 40% |
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Mendeley readers
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Researcher | 11 | 32% |
Other | 2 | 6% |
Student > Doctoral Student | 2 | 6% |
Student > Postgraduate | 2 | 6% |
Student > Master | 2 | 6% |
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Unknown | 11 | 32% |
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Mathematics | 1 | 3% |
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Materials Science | 1 | 3% |
Other | 0 | 0% |
Unknown | 15 | 44% |