| Title |
The mechanisms of action of valproate in neuropsychiatric disorders: can we see the forest for the trees?
|
|---|---|
| Published in |
Cellular and Molecular Life Sciences, May 2007
|
| DOI | 10.1007/s00018-007-7079-x |
| Pubmed ID | |
| Authors |
G. Rosenberg |
| Abstract |
After more than 40 years of clinical use, the mechanisms of action of valproate in epilepsy, bipolar disorder and migraine are still not fully understood. However, recent findings reviewed here shed new light on the cellular effects of valproate. Beyond the enhancement of gamma-aminobutyric acid-mediated neurotransmission, valproate has been found to affect signalling systems like the Wnt/beta-catenin and ERK pathways and to interfere with inositol and arachidonate metabolism. Nevertheless, the clinical relevance of these effects is not always clear. Valproate treatment also produces marked alterations in the expression of multiple genes, many of which are involved in transcription regulation, cell survival, ion homeostasis, cytoskeletal modifications and signal transduction. These alterations may well be relevant to the therapeutic effects of valproate, and result from its enhancement of activator protein-1 DNA binding and direct inhibition of histone deacetylases, and possibly additional, yet unknown, mechanism(s). Most likely, both immediate biochemical and longer-term genomic influences underlie the effects of valproate in all three indications. |
Mendeley readers
The data shown below were compiled from readership statistics for 216 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 4 | 2% |
| Netherlands | 1 | <1% |
| Germany | 1 | <1% |
| Brazil | 1 | <1% |
| United States | 1 | <1% |
| Unknown | 208 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 40 | 19% |
| Researcher | 39 | 18% |
| Student > Ph. D. Student | 26 | 12% |
| Student > Master | 20 | 9% |
| Professor > Associate Professor | 14 | 6% |
| Other | 41 | 19% |
| Unknown | 36 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 61 | 28% |
| Medicine and Dentistry | 32 | 15% |
| Neuroscience | 24 | 11% |
| Biochemistry, Genetics and Molecular Biology | 17 | 8% |
| Psychology | 10 | 5% |
| Other | 25 | 12% |
| Unknown | 47 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 12. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 May 2022.
All research outputs
#2,605,950
of 23,794,258 outputs
Outputs from Cellular and Molecular Life Sciences
#363
of 4,151 outputs
Outputs of similar age
#5,800
of 72,328 outputs
Outputs of similar age from Cellular and Molecular Life Sciences
#3
of 38 outputs
Altmetric has tracked 23,794,258 research outputs across all sources so far. Compared to these this one has done well and is in the 88th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,151 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.0. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 72,328 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 91% of its contemporaries.
We're also able to compare this research output to 38 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 92% of its contemporaries.