| Title |
Neuroimaging study of placebo analgesia in humans
|
|---|---|
| Published in |
Neuroscience Bulletin, October 2009
|
| DOI | 10.1007/s12264-009-0907-2 |
| Pubmed ID | |
| Authors |
Yun-Hai Qiu, Xin-Yin Wu, Hao Xu, David Sackett |
| Abstract |
Placebo has been reported to exert beneficial effects in patients regarding the treatment of pain. Human functional neuroimaging technology can study the intact human brain to elucidate its functional neuroanatomy and the neurobiological mechanism of the placebo effect. Blood flow measurement using functional magnetic resonance imaging and positron emission tomography (PET) has revealed that analgesia is related to decreased neural activities in pain-modulatory brain regions, such as the rostral anterior cingulate cortex (rACC), insula, thalamus, and brainstem including periaqueductal gray (PAG) and ventromedial medulla. The endogenous opioid system and its activation of mu-opioid receptors are thought to mediate the observed effects of placebo. The mu-opioid receptor-selective radiotracer-labeled PET studies show that the placebo effects are accompanied by reduction in activation of opioid neural transmission in pain-sensitive brain regions, including rACC, prefrontal cortex, insula, thalamus, amygdala, nucleus accumbens (NAC) and PAG. Further PET studies with dopamine D2/D3 receptor-labeling radiotracer demonstrate that basal ganglia including NAC are related to placebo analgesic responses. NAC dopamine release induced by placebo analgesia is related to expectation of analgesia. These data indicate that the aforementioned brain regions and neurotransmitters such as endogenous opioid and dopamine systems contribute to placebo analgesia. |
Mendeley readers
The data shown below were compiled from readership statistics for 67 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 3 | 4% |
| United States | 3 | 4% |
| Netherlands | 1 | 1% |
| Unknown | 60 | 90% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 13 | 19% |
| Student > Master | 11 | 16% |
| Student > Bachelor | 9 | 13% |
| Professor > Associate Professor | 6 | 9% |
| Student > Ph. D. Student | 5 | 7% |
| Other | 14 | 21% |
| Unknown | 9 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 15 | 22% |
| Neuroscience | 13 | 19% |
| Agricultural and Biological Sciences | 8 | 12% |
| Nursing and Health Professions | 7 | 10% |
| Psychology | 7 | 10% |
| Other | 6 | 9% |
| Unknown | 11 | 16% |
Attention Score in Context
This research output has an Altmetric Attention Score of 12. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 July 2011.
All research outputs
#2,857,609
of 25,388,837 outputs
Outputs from Neuroscience Bulletin
#59
of 913 outputs
Outputs of similar age
#9,703
of 106,508 outputs
Outputs of similar age from Neuroscience Bulletin
#1
of 1 outputs
Altmetric has tracked 25,388,837 research outputs across all sources so far. Compared to these this one has done well and is in the 88th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 913 research outputs from this source. They receive a mean Attention Score of 4.1. This one has done particularly well, scoring higher than 93% of its peers.
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