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Developmental pathways inferred from modularity, morphological integration and fluctuating asymmetry patterns in the human face

Overview of attention for article published in Scientific Reports, January 2018
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  • Good Attention Score compared to outputs of the same age (69th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (63rd percentile)

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Title
Developmental pathways inferred from modularity, morphological integration and fluctuating asymmetry patterns in the human face
Published in
Scientific Reports, January 2018
DOI 10.1038/s41598-018-19324-y
Pubmed ID
Authors

Mirsha Quinto-Sánchez, Francesc Muñoz-Muñoz, Jorge Gomez-Valdes, Celia Cintas, Pablo Navarro, Caio Cesar Silva de Cerqueira, Carolina Paschetta, Soledad de Azevedo, Virginia Ramallo, Victor Acuña-Alonzo, Kaustubh Adhikari, Macarena Fuentes-Guajardo, Tábita Hünemeier, Paola Everardo, Francisco de Avila, Claudia Jaramillo, Williams Arias, Carla Gallo, Giovani Poletti, Gabriel Bedoya, Maria Cátira Bortolini, Samuel Canizales-Quinteros, Francisco Rothhammer, Javier Rosique, Andres Ruiz-Linares, Rolando Gonzalez-Jose

Abstract

Facial asymmetries are usually measured and interpreted as proxies to developmental noise. However, analyses focused on its developmental and genetic architecture are scarce. To advance on this topic, studies based on a comprehensive and simultaneous analysis of modularity, morphological integration and facial asymmetries including both phenotypic and genomic information are needed. Here we explore several modularity hypotheses on a sample of Latin American mestizos, in order to test if modularity and integration patterns differ across several genomic ancestry backgrounds. To do so, 4104 individuals were analyzed using 3D photogrammetry reconstructions and a set of 34 facial landmarks placed on each individual. We found a pattern of modularity and integration that is conserved across sub-samples differing in their genomic ancestry background. Specifically, a signal of modularity based on functional demands and organization of the face is regularly observed across the whole sample. Our results shed more light on previous evidence obtained from Genome Wide Association Studies performed on the same samples, indicating the action of different genomic regions contributing to the expression of the nose and mouth facial phenotypes. Our results also indicate that large samples including phenotypic and genomic metadata enable a better understanding of the developmental and genetic architecture of craniofacial phenotypes.

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X Demographics

The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 66 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 66 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 11 17%
Student > Master 9 14%
Student > Doctoral Student 7 11%
Researcher 6 9%
Student > Bachelor 4 6%
Other 16 24%
Unknown 13 20%
Readers by discipline Count As %
Agricultural and Biological Sciences 12 18%
Medicine and Dentistry 9 14%
Biochemistry, Genetics and Molecular Biology 7 11%
Arts and Humanities 5 8%
Computer Science 4 6%
Other 11 17%
Unknown 18 27%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 February 2018.
All research outputs
#6,938,163
of 24,348,815 outputs
Outputs from Scientific Reports
#47,375
of 132,444 outputs
Outputs of similar age
#135,642
of 450,299 outputs
Outputs of similar age from Scientific Reports
#1,468
of 4,010 outputs
Altmetric has tracked 24,348,815 research outputs across all sources so far. This one has received more attention than most of these and is in the 71st percentile.
So far Altmetric has tracked 132,444 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 18.6. This one has gotten more attention than average, scoring higher than 63% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 450,299 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 69% of its contemporaries.
We're also able to compare this research output to 4,010 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 63% of its contemporaries.