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Mendeley readers
Attention Score in Context
| Title |
Maintenance of the correct open reading frame by the ribosome
|
|---|---|
| Published in |
EMBO Reports, April 2003
|
| DOI | 10.1038/sj.embor.embor825 |
| Pubmed ID | |
| Authors |
Thomas M Hansen, Pavel V Baranov, Ivaylo P Ivanov, Raymond F Gesteland, John F Atkins |
| Abstract |
During translation, a string of non-overlapping triplet codons in messenger RNA is decoded into protein. The ability of a ribosome to decode mRNA without shifting between reading frames is a strict requirement for accurate protein biosynthesis. Despite enormous progress in understanding the mechanism of transfer RNA selection, the mechanism by which the correct reading frame is maintained remains unclear. In this report, evidence is presented that supports the idea that the translational frame is controlled mainly by the stability of codon-anticodon interactions at the P site. The relative instability of such interactions may lead to dissociation of the P-site tRNA from its codon, and formation of a complex with an overlapping codon, the process known as P-site tRNA slippage. We propose that this process is central to all known cases of +1 ribosomal frameshifting, including that required for the decoding of the yeast transposable element Ty3. An earlier model for the decoding of this element proposed 'out-of-frame' binding of A-site tRNA without preceding P-site tRNA slippage. |
Mendeley readers
The data shown below were compiled from readership statistics for 62 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 3% |
| Israel | 1 | 2% |
| Unknown | 59 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 16 | 26% |
| Researcher | 11 | 18% |
| Student > Bachelor | 8 | 13% |
| Professor | 7 | 11% |
| Professor > Associate Professor | 7 | 11% |
| Other | 7 | 11% |
| Unknown | 6 | 10% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 29 | 47% |
| Biochemistry, Genetics and Molecular Biology | 17 | 27% |
| Computer Science | 2 | 3% |
| Physics and Astronomy | 2 | 3% |
| Medicine and Dentistry | 2 | 3% |
| Other | 4 | 6% |
| Unknown | 6 | 10% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 July 2020.
All research outputs
#7,451,942
of 22,782,096 outputs
Outputs from EMBO Reports
#2,110
of 3,680 outputs
Outputs of similar age
#16,870
of 50,596 outputs
Outputs of similar age from EMBO Reports
#25
of 42 outputs
Altmetric has tracked 22,782,096 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,680 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 12.9. This one is in the 30th percentile – i.e., 30% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 50,596 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 12th percentile – i.e., 12% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 42 others from the same source and published within six weeks on either side of this one. This one is in the 9th percentile – i.e., 9% of its contemporaries scored the same or lower than it.