| Title |
Transformation: how do nematode sperm become activated and crawl?
|
|---|---|
| Published in |
Protein & Cell, August 2012
|
| DOI | 10.1007/s13238-012-2936-2 |
| Pubmed ID | |
| Authors |
Xuan Ma, Yanmei Zhao, Wei Sun, Katsuya Shimabukuro, Long Miao |
| Abstract |
Nematode sperm undergo a drastic physiological change during spermiogenesis (sperm activation). Unlike mammalian flagellated sperm, nematode sperm are amoeboid cells and their motility is driven by the dynamics of a cytoskeleton composed of major sperm protein (MSP) rather than actin found in other crawling cells. This review focuses on sperm from Caenorhabditis elegans and Ascaris suum to address the roles of external and internal factors that trigger sperm activation and power sperm motility. Nematode sperm can be activated in vitro by several factors, including Pronase and ionophores, and in vivo through the TRY-5 and SPE-8 pathways. Moreover, protease and protease inhibitors are crucial regulators of sperm maturation. MSP-based sperm motility involves a coupled process of protrusion and retraction, both of which have been reconstituted in vitro. Sperm motility is mediated by phosphorylation signals, as illustrated by identification of several key components (MPOP, MFPs and MPAK) in Ascaris and the characterization of GSP-3/4 in C. elegans. |
Mendeley readers
The data shown below were compiled from readership statistics for 38 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Switzerland | 1 | 3% |
| Unknown | 37 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 16 | 42% |
| Student > Master | 7 | 18% |
| Student > Ph. D. Student | 5 | 13% |
| Researcher | 2 | 5% |
| Student > Doctoral Student | 1 | 3% |
| Other | 1 | 3% |
| Unknown | 6 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 21 | 55% |
| Medicine and Dentistry | 4 | 11% |
| Biochemistry, Genetics and Molecular Biology | 3 | 8% |
| Mathematics | 1 | 3% |
| Nursing and Health Professions | 1 | 3% |
| Other | 1 | 3% |
| Unknown | 7 | 18% |
Attention Score in Context
This research output has an Altmetric Attention Score of 11. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 October 2023.
All research outputs
#3,003,517
of 24,586,986 outputs
Outputs from Protein & Cell
#119
of 799 outputs
Outputs of similar age
#19,488
of 174,920 outputs
Outputs of similar age from Protein & Cell
#1
of 9 outputs
Altmetric has tracked 24,586,986 research outputs across all sources so far. Compared to these this one has done well and is in the 87th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
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