| Title |
The Role of Taurine in the Central Nervous System and the Modulation of Intracellular Calcium Homeostasis
|
|---|---|
| Published in |
Neurochemical Research, February 2002
|
| DOI | 10.1023/a:1014890219513 |
| Pubmed ID | |
| Authors |
Todd M. Foos, Jang-Yen Wu |
| Abstract |
The effects of taurine in the mammalian nervous system are numerous and varied. There has been great difficulty in determining the specific targets of taurine action. The authors present a review of accepted taurine action and highlight recent discoveries regarding taurine and calcium homeostasis in neurons. In general there is a consensus that taurine is a powerful agent in regulating and reducing the intracellular calcium levels in neurons. After prolonged L-glutamate stimulation, neurons lose the ability to effectively regulate intracellular calcium. This condition can lead to acute swelling and lysis of the cell, or culminate in apoptosis. Under these conditions, significant amounts of taurine (mM range) are released from the excited neuron. This extracellular taurine acts to slow the influx of calcium into the cytosol through both transmembrane ion transporters and intracellular storage pools. Two specific targets of taurine action are discussed: Na(+)-Ca2+ exchangers, and metabotropic receptors mediating phospholipase-C. |
Mendeley readers
The data shown below were compiled from readership statistics for 53 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 4% |
| Poland | 1 | 2% |
| Germany | 1 | 2% |
| Unknown | 49 | 92% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 15 | 28% |
| Student > Ph. D. Student | 8 | 15% |
| Researcher | 8 | 15% |
| Professor | 3 | 6% |
| Professor > Associate Professor | 3 | 6% |
| Other | 10 | 19% |
| Unknown | 6 | 11% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 18 | 34% |
| Medicine and Dentistry | 9 | 17% |
| Biochemistry, Genetics and Molecular Biology | 5 | 9% |
| Pharmacology, Toxicology and Pharmaceutical Science | 5 | 9% |
| Engineering | 3 | 6% |
| Other | 7 | 13% |
| Unknown | 6 | 11% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 January 2022.
All research outputs
#8,535,472
of 25,374,917 outputs
Outputs from Neurochemical Research
#663
of 2,262 outputs
Outputs of similar age
#33,342
of 132,991 outputs
Outputs of similar age from Neurochemical Research
#2
of 5 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,262 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.9. This one is in the 47th percentile – i.e., 47% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 132,991 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 16th percentile – i.e., 16% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 5 others from the same source and published within six weeks on either side of this one. This one has scored higher than 3 of them.