| Title |
The role of Sonic hedgehog in neural tube patterning
|
|---|---|
| Published in |
Cellular and Molecular Life Sciences, November 2000
|
| DOI | 10.1007/pl00000652 |
| Pubmed ID | |
| Authors |
I. Patten, M. Placzek* |
| Abstract |
In the developing neural tube of vertebrate embryos, many types of neuronal and nonneuronal cells differentiate in response to the secreted signalling molecule, Shh. Shh shows a spatially restricted pattern of expression in cells located at the ventral midline, yet governs the differentiation of diverse cell types throughout the ventral half of the neural tube. Here, we describe how the distinct fate assumed by cells in response to Shh is dependent upon their position with respect to both the dorso-ventral and anterior-posterior axes of the neural tube and describe the ways in which a single factor, Shh, is able to pattern the developing nervous system. We first discuss the evidence that Shh does impose ventral identity on cells in the neural tube, then focus on the role of a graded Shh signal in patterning the neural tube and finally discuss the interaction of Shh with other factors that affect its signalling outcome. |
Mendeley readers
The data shown below were compiled from readership statistics for 138 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 2% |
| Brazil | 2 | 1% |
| Canada | 1 | <1% |
| Unknown | 132 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 33 | 24% |
| Student > Bachelor | 29 | 21% |
| Student > Master | 15 | 11% |
| Researcher | 10 | 7% |
| Student > Doctoral Student | 8 | 6% |
| Other | 16 | 12% |
| Unknown | 27 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 40 | 29% |
| Biochemistry, Genetics and Molecular Biology | 29 | 21% |
| Neuroscience | 25 | 18% |
| Medicine and Dentistry | 10 | 7% |
| Engineering | 3 | 2% |
| Other | 3 | 2% |
| Unknown | 28 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 December 2023.
All research outputs
#8,534,528
of 25,371,288 outputs
Outputs from Cellular and Molecular Life Sciences
#2,145
of 5,876 outputs
Outputs of similar age
#13,811
of 41,049 outputs
Outputs of similar age from Cellular and Molecular Life Sciences
#15
of 22 outputs
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