| Title |
Neurotoxicity of Prosopis juliflora: from Natural Poisoning to Mechanism of Action of Its Piperidine Alkaloids
|
|---|---|
| Published in |
Neurotoxicity Research, January 2018
|
| DOI | 10.1007/s12640-017-9862-2 |
| Pubmed ID | |
| Authors |
Victor Diogenes Amaral da Silva, André Mario Mendes da Silva, Juliana Helena Castro e Silva, Silvia Lima Costa |
| Abstract |
Prosopis juliflora was introduced in northeastern Brazil in the 1940s, and since then, it has been available as an alternative for animal nutrition. However, the consumption of P. juliflora as main or sole source of food causes an illness in animals known locally as "cara torta" disease. Cattle and goats experimentally intoxicated presents neurotoxic damage in the central nervous system. Histologic lesions were mainly characterized by vacuolation and loss of neurons in trigeminal motor nuclei. Furthermore, mitochondrial damage in neurons and gliosis was reported in trigeminal nuclei of intoxicated cattle. Studies, using neural cell cultures, have reproduced the main cellular alterations visualized in cara torta disease and contributed to understanding the mechanism of action piperidine alkaloids, the main neurotoxic compound in P. juliflora leaves and pods. Here, we will present aspects of the biological and toxicological properties of P. juliflora and its pharmacologically active compounds. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 3 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 32 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 32 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 6 | 19% |
| Student > Doctoral Student | 5 | 16% |
| Student > Master | 3 | 9% |
| Professor > Associate Professor | 3 | 9% |
| Researcher | 3 | 9% |
| Other | 2 | 6% |
| Unknown | 10 | 31% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 4 | 13% |
| Environmental Science | 2 | 6% |
| Veterinary Science and Veterinary Medicine | 2 | 6% |
| Neuroscience | 2 | 6% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 6% |
| Other | 10 | 31% |
| Unknown | 10 | 31% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 January 2018.
All research outputs
#14,964,325
of 23,016,919 outputs
Outputs from Neurotoxicity Research
#513
of 887 outputs
Outputs of similar age
#256,388
of 442,088 outputs
Outputs of similar age from Neurotoxicity Research
#10
of 16 outputs
Altmetric has tracked 23,016,919 research outputs across all sources so far. This one is in the 32nd percentile – i.e., 32% of other outputs scored the same or lower than it.
So far Altmetric has tracked 887 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.3. This one is in the 39th percentile – i.e., 39% of its peers scored the same or lower than it.
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We're also able to compare this research output to 16 others from the same source and published within six weeks on either side of this one. This one is in the 31st percentile – i.e., 31% of its contemporaries scored the same or lower than it.