| Title |
Reviews in Molecular Biology and Biotechnology: Transmembrane Signaling by G Protein-Coupled Receptors
|
|---|---|
| Published in |
Molecular Biotechnology, February 2008
|
| DOI | 10.1007/s12033-008-9031-1 |
| Pubmed ID | |
| Authors |
Louis M. Luttrell |
| Abstract |
As the most diverse type of cell surface receptor, the importance heptahelical G protein-coupled receptors (GPCRs) to clinical medicine cannot be overestimated. Visual, olfactory and gustatory sensation, intermediary metabolism, cell growth and differentiation are all influenced by GPCR signals. The basic receptor-G protein-effector mechanism of GPCR signaling is tuned by a complex interplay of positive and negative regulatory events that amplify the effect of a hormone binding the receptor or that dampen cellular responsiveness. The association of heptahelical receptors with a variety of intracellular partners other than G proteins has led to the discovery of potential mechanisms of GPCR signaling that extend beyond the classical paradigms. While the physiologic relevance of many of these novel mechanisms of GPCR signaling remains to be established, their existence suggests that the mechanisms of GPCR signaling are even more diverse than previously imagined. |
Mendeley readers
The data shown below were compiled from readership statistics for 164 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 4 | 2% |
| United States | 3 | 2% |
| Denmark | 1 | <1% |
| Netherlands | 1 | <1% |
| Unknown | 155 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 40 | 24% |
| Student > Master | 25 | 15% |
| Student > Bachelor | 18 | 11% |
| Researcher | 17 | 10% |
| Professor | 13 | 8% |
| Other | 20 | 12% |
| Unknown | 31 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 60 | 37% |
| Biochemistry, Genetics and Molecular Biology | 18 | 11% |
| Medicine and Dentistry | 18 | 11% |
| Pharmacology, Toxicology and Pharmaceutical Science | 10 | 6% |
| Neuroscience | 10 | 6% |
| Other | 14 | 9% |
| Unknown | 34 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 January 2021.
All research outputs
#4,694,742
of 22,782,096 outputs
Outputs from Molecular Biotechnology
#118
of 959 outputs
Outputs of similar age
#22,760
of 156,874 outputs
Outputs of similar age from Molecular Biotechnology
#1
of 11 outputs
Altmetric has tracked 22,782,096 research outputs across all sources so far. Compared to these this one has done well and is in the 76th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 959 research outputs from this source. They receive a mean Attention Score of 3.5. This one has done well, scoring higher than 75% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 156,874 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 79% of its contemporaries.
We're also able to compare this research output to 11 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.