| Title |
Sperm DNA integrity assays: diagnostic and prognostic challenges and implications in management of infertility
|
|---|---|
| Published in |
Journal of Assisted Reproduction and Genetics, September 2011
|
| DOI | 10.1007/s10815-011-9631-8 |
| Pubmed ID | |
| Authors |
Monis Bilal Shamsi, Syed Nazar Imam, Rima Dada |
| Abstract |
Sperm is not a simple carrier of paternal genetic information but its role extends clearly beyond fertilization. Integrity of sperm genome is an essential pre-requisite for birth of healthy offspring and evaluation of sperm should entail DNA integrity analysis. DNA integrity analysis is a better diagnostic and prognostic marker of sperm reproductive potential. Conventional semen analysis emphasizes on sperm concentration, viability, motility and morphology and has been proven to be a poor indicator of reproductive potential and pregnancy outcome. To overcome the drawbacks associated with conventional semen analysis more useful fertility tests and molecular biomarkers have been explored. Among the different tests which have evolved for assessing the sperm reproductive potential, tests for sperm DNA quality are most promising. Sperm DNA damage has been closely associated with numerous indicators of reproductive health including fertilization, embryo quality, implantation, spontaneous abortion, congenital malformations and childhood diseases. It therefore has great potential as a prognostic test for both in vitro and in vivo conception. This review presents an updated account of tests that have better diagnostic and prognostic implications in the evaluation of sperm DNA damage. The basic principles, outline of methodology, advantage, disadvantage, clinical significance of each technique and implications of these tests have been discussed. The logistics of each test with respect to available resources and equipment in an andrology laboratory, the feasibility of performing these tests in routine diagnostic workup of infertile men and the opportunities and challenges provided by DNA testing in male fertility determination are also presented. |
Mendeley readers
The data shown below were compiled from readership statistics for 210 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Iran, Islamic Republic of | 1 | <1% |
| Spain | 1 | <1% |
| Canada | 1 | <1% |
| Unknown | 207 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 33 | 16% |
| Student > Ph. D. Student | 32 | 15% |
| Student > Bachelor | 27 | 13% |
| Researcher | 23 | 11% |
| Student > Postgraduate | 14 | 7% |
| Other | 29 | 14% |
| Unknown | 52 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 47 | 22% |
| Medicine and Dentistry | 39 | 19% |
| Biochemistry, Genetics and Molecular Biology | 29 | 14% |
| Engineering | 9 | 4% |
| Nursing and Health Professions | 8 | 4% |
| Other | 24 | 11% |
| Unknown | 54 | 26% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 September 2019.
All research outputs
#5,089,278
of 24,119,703 outputs
Outputs from Journal of Assisted Reproduction and Genetics
#258
of 1,697 outputs
Outputs of similar age
#27,177
of 128,940 outputs
Outputs of similar age from Journal of Assisted Reproduction and Genetics
#1
of 6 outputs
Altmetric has tracked 24,119,703 research outputs across all sources so far. Compared to these this one has done well and is in the 75th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,697 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.8. This one has done well, scoring higher than 81% of its peers.
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We're also able to compare this research output to 6 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them