| Title |
Highly favorable physiological responses to concurrent resistance and high-intensity interval training during chemotherapy: the OptiTrain breast cancer trial
|
|---|---|
| Published in |
Breast Cancer Research and Treatment, January 2018
|
| DOI | 10.1007/s10549-018-4663-8 |
| Pubmed ID | |
| Authors |
Sara Mijwel, Malin Backman, Kate A. Bolam, Emil Olofsson, Jessica Norrbom, Jonas Bergh, Carl Johan Sundberg, Yvonne Wengström, Helene Rundqvist |
| Abstract |
Advanced therapeutic strategies are often accompanied by significant adverse effects, which warrant equally progressive countermeasures. Physical exercise has proven an effective intervention to improve physical function and reduce fatigue in patients undergoing chemotherapy. Effects of high-intensity interval training (HIIT) in this population are not well established although HIIT has proven effective in other clinical populations. The aim of the OptiTrain trial was to examine the effects of concurrent resistance and high-intensity interval training (RT-HIIT) or concurrent moderate-intensity aerobic and high-intensity interval training (AT-HIIT), to usual care (UC) on pain sensitivity and physiological outcomes in patients with breast cancer during chemotherapy. Two hundred and forty women were randomized to 16 weeks of RT-HIIT, AT-HIIT, or UC. cardiorespiratory fitness, muscle strength, body mass, hemoglobin levels, and pressure-pain threshold. Pre- to post-intervention, RT-HIIT (ES = 0.41) and AT-HIIT (ES = 0.42) prevented the reduced cardiorespiratory fitness found with UC. Handgrip strength (surgery side: RT-HIIT vs. UC: ES = 0.41, RT-HIIT vs. ES = 0.28; non-surgery side: RT-HIIT vs. UC: ES = 0.35, RT-HIIT vs. ES = 0.22) and lower-limb muscle strength (RT-HIIT vs. UC: ES = 0.66, RT-HIIT vs. ES = 0.23) were significantly improved in the RT-HIIT. Increases in body mass were smaller in RT-HIIT (ES = - 0.16) and AT-HIIT (ES = - 0.16) versus UC. RT-HIIT reported higher pressure-pain thresholds than UC (trapezius: ES = 0.46, gluteus: ES = 0.53) and AT-HIIT (trapezius: ES = 0.30). Sixteen weeks of RT-HIIT significantly improved muscle strength and reduced pain sensitivity. Both exercise programs were well tolerated and were equally efficient in preventing increases in body mass and in preventing declines in cardiorespiratory fitness. These results highlight the importance of implementing a combination of resistance and high-intensity interval training during chemotherapy for women with breast cancer. |
X Demographics
The data shown below were collected from the profiles of 42 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 8 | 19% |
| Sweden | 5 | 12% |
| Australia | 4 | 10% |
| Canada | 4 | 10% |
| United Kingdom | 2 | 5% |
| Colombia | 1 | 2% |
| Norway | 1 | 2% |
| Brazil | 1 | 2% |
| Spain | 1 | 2% |
| Other | 4 | 10% |
| Unknown | 11 | 26% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 24 | 57% |
| Scientists | 16 | 38% |
| Practitioners (doctors, other healthcare professionals) | 2 | 5% |
Mendeley readers
The data shown below were compiled from readership statistics for 558 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 558 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 75 | 13% |
| Student > Master | 72 | 13% |
| Student > Ph. D. Student | 36 | 6% |
| Student > Postgraduate | 33 | 6% |
| Researcher | 28 | 5% |
| Other | 75 | 13% |
| Unknown | 239 | 43% |
| Readers by discipline | Count | As % |
|---|---|---|
| Nursing and Health Professions | 101 | 18% |
| Medicine and Dentistry | 78 | 14% |
| Sports and Recreations | 74 | 13% |
| Biochemistry, Genetics and Molecular Biology | 14 | 3% |
| Social Sciences | 7 | 1% |
| Other | 32 | 6% |
| Unknown | 252 | 45% |
Attention Score in Context
This research output has an Altmetric Attention Score of 37. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 June 2023.
All research outputs
#1,049,580
of 24,674,353 outputs
Outputs from Breast Cancer Research and Treatment
#111
of 4,889 outputs
Outputs of similar age
#25,292
of 452,085 outputs
Outputs of similar age from Breast Cancer Research and Treatment
#4
of 77 outputs
Altmetric has tracked 24,674,353 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,889 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.3. This one has done particularly well, scoring higher than 97% of its peers.
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We're also able to compare this research output to 77 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 96% of its contemporaries.