| Title |
Phosphodiesterase: overview of protein structures, potential therapeutic applications and recent progress in drug development
|
|---|---|
| Published in |
Cellular and Molecular Life Sciences, March 2005
|
| DOI | 10.1007/s00018-005-4533-5 |
| Pubmed ID | |
| Authors |
Y. H. Jeon, Y. -S. Heo, C. M. Kim, Y. -L. Hyun, T. G. Lee, S. Ro, J. M. Cho |
| Abstract |
Phosphodiesterases (PDEs) are essential regulators of cyclic nucleotide signaling with diverse physiological functions. Because of their great market potential and therapeutic importance, PDE inhibitors became recognized as important therapeutic agents in the treatment of various diseases. Currently, there are seven PDE inhibitors on the market, and the pharmacological and safety evaluations of many drug candidates are in progress. Three-dimensional (3D) structures of catalytic domains of PDE 1, -3, -4, -5 and -9 in the presence of their inhibitors are now available, and can be utilized for rational drug design. Recent advances in molecular pharmacology of PDE isoenzymes resulted in identification of new potential applications of PDE inhibitors in various therapeutic areas, including dementia, depression and schizophrenia. This review will describe the latest advances in PDE research on 3D structural studies, the potential of therapeutic applications and the development of drug candidates. |
Mendeley readers
The data shown below were compiled from readership statistics for 180 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 1% |
| Germany | 1 | <1% |
| Netherlands | 1 | <1% |
| Indonesia | 1 | <1% |
| Portugal | 1 | <1% |
| Brazil | 1 | <1% |
| Chile | 1 | <1% |
| Singapore | 1 | <1% |
| United Kingdom | 1 | <1% |
| Other | 0 | 0% |
| Unknown | 170 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 33 | 18% |
| Researcher | 29 | 16% |
| Student > Master | 25 | 14% |
| Student > Bachelor | 24 | 13% |
| Student > Postgraduate | 8 | 4% |
| Other | 26 | 14% |
| Unknown | 35 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 41 | 23% |
| Biochemistry, Genetics and Molecular Biology | 23 | 13% |
| Pharmacology, Toxicology and Pharmaceutical Science | 19 | 11% |
| Medicine and Dentistry | 19 | 11% |
| Chemistry | 16 | 9% |
| Other | 23 | 13% |
| Unknown | 39 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 May 2023.
All research outputs
#4,965,094
of 23,794,258 outputs
Outputs from Cellular and Molecular Life Sciences
#928
of 4,151 outputs
Outputs of similar age
#10,966
of 60,597 outputs
Outputs of similar age from Cellular and Molecular Life Sciences
#11
of 31 outputs
Altmetric has tracked 23,794,258 research outputs across all sources so far. Compared to these this one has done well and is in the 76th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,151 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.0. This one has gotten more attention than average, scoring higher than 70% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 60,597 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 71% of its contemporaries.
We're also able to compare this research output to 31 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 58% of its contemporaries.