| Title |
Caspase-1-Mediated Pyroptosis of the Predominance for Driving CD4+ T Cells Death: A Nonlocal Spatial Mathematical Model
|
|---|---|
| Published in |
Bulletin of Mathematical Biology, January 2018
|
| DOI | 10.1007/s11538-017-0389-8 |
| Pubmed ID | |
| Authors |
Wei Wang, Tongqian Zhang |
| Abstract |
Caspase-1-mediated pyroptosis is the predominance for driving CD4[Formula: see text] T cells death. Dying infected CD4[Formula: see text] T cells can release inflammatory signals which attract more uninfected CD4[Formula: see text] T cells to die. This paper is devoted to developing a diffusive mathematical model which can make useful contributions to understanding caspase-1-mediated pyroptosis by inflammatory cytokines IL-1[Formula: see text] released from infected cells in the within-host environment. The well-posedness of solutions, basic reproduction number, threshold dynamics are investigated for spatially heterogeneous infection. Travelling wave solutions for spatially homogeneous infection are studied. Numerical computations reveal that the spatially heterogeneous infection can make [Formula: see text], that is, it can induce the persistence of virus compared to the spatially homogeneous infection. We also find that the random movements of virus have no effect on basic reproduction number for the spatially homogeneous model, while it may result in less infection risk for the spatially heterogeneous model, under some suitable parameters. Further, the death of infected CD4[Formula: see text] cells which are caused by pyroptosis can make [Formula: see text], that is, it can induce the extinction of virus, regardless of whether or not the parameters are spatially dependent. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 4 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 2 | 50% |
| Members of the public | 2 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 16 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 16 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 3 | 19% |
| Other | 2 | 13% |
| Student > Doctoral Student | 2 | 13% |
| Student > Master | 1 | 6% |
| Professor > Associate Professor | 1 | 6% |
| Other | 1 | 6% |
| Unknown | 6 | 38% |
| Readers by discipline | Count | As % |
|---|---|---|
| Nursing and Health Professions | 2 | 13% |
| Mathematics | 2 | 13% |
| Medicine and Dentistry | 2 | 13% |
| Immunology and Microbiology | 1 | 6% |
| Biochemistry, Genetics and Molecular Biology | 1 | 6% |
| Other | 0 | 0% |
| Unknown | 8 | 50% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 March 2018.
All research outputs
#13,225,966
of 23,016,919 outputs
Outputs from Bulletin of Mathematical Biology
#508
of 1,103 outputs
Outputs of similar age
#211,420
of 441,922 outputs
Outputs of similar age from Bulletin of Mathematical Biology
#14
of 32 outputs
Altmetric has tracked 23,016,919 research outputs across all sources so far. This one is in the 42nd percentile – i.e., 42% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,103 research outputs from this source. They receive a mean Attention Score of 4.7. This one has gotten more attention than average, scoring higher than 52% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 441,922 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 51% of its contemporaries.
We're also able to compare this research output to 32 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 53% of its contemporaries.