| Title |
Pentraxins in Innate Immunity: From C-Reactive Protein to the Long Pentraxin PTX3
|
|---|---|
| Published in |
Journal of Clinical Immunology, September 2007
|
| DOI | 10.1007/s10875-007-9126-7 |
| Pubmed ID | |
| Authors |
Alberto Mantovani, Cecilia Garlanda, Andrea Doni, Barbara Bottazzi |
| Abstract |
Pentraxins are a family of multimeric pattern-recognition proteins highly conserved in evolution. Based on the primary structure of the subunit, the pentraxins are divided into two groups: short pentraxins and long pentraxins. C-reactive protein and serum amyloid P-component are classic short pentraxins produced in the liver, whereas the prototype of the long pentraxin family is PTX3. Innate immunity cells and vascular cells produce PTX3 in response to proinflammatory signals and Toll-like receptor engagement. PTX3 interacts with several ligands, including growth factors, extracellular matrix components, and selected pathogens, playing a role in complement activation, facilitating pathogen recognition, and acting as a predecessor of antibodies. In addition, PTX3 is essential in female fertility acting on the assembly of the cumulus oophorus extracellular matrix. Thus, PTX3 is a multifunctional soluble pattern recognition receptor acting as a nonredundant component of the humoral arm of innate immunity and involved in tuning inflammation, in matrix deposition and female fertility. Evidence suggests that PTX3 is a useful new serological marker, rapidly reflecting tissue inflammation and damage under diverse clinical conditions. |
Mendeley readers
The data shown below were compiled from readership statistics for 222 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 2 | <1% |
| Netherlands | 1 | <1% |
| Brazil | 1 | <1% |
| Sweden | 1 | <1% |
| India | 1 | <1% |
| United Kingdom | 1 | <1% |
| Slovenia | 1 | <1% |
| Denmark | 1 | <1% |
| Japan | 1 | <1% |
| Other | 1 | <1% |
| Unknown | 211 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 42 | 19% |
| Researcher | 36 | 16% |
| Student > Master | 30 | 14% |
| Student > Bachelor | 22 | 10% |
| Student > Postgraduate | 9 | 4% |
| Other | 29 | 13% |
| Unknown | 54 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 64 | 29% |
| Agricultural and Biological Sciences | 41 | 18% |
| Biochemistry, Genetics and Molecular Biology | 18 | 8% |
| Immunology and Microbiology | 14 | 6% |
| Nursing and Health Professions | 6 | 3% |
| Other | 20 | 9% |
| Unknown | 59 | 27% |
Attention Score in Context
This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 January 2024.
All research outputs
#3,271,353
of 22,782,096 outputs
Outputs from Journal of Clinical Immunology
#168
of 1,556 outputs
Outputs of similar age
#8,048
of 69,959 outputs
Outputs of similar age from Journal of Clinical Immunology
#2
of 5 outputs
Altmetric has tracked 22,782,096 research outputs across all sources so far. Compared to these this one has done well and is in the 84th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,556 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.4. This one has done well, scoring higher than 87% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 69,959 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 85% of its contemporaries.
We're also able to compare this research output to 5 others from the same source and published within six weeks on either side of this one. This one has scored higher than 3 of them.