| Title |
Regulation of eukaryotic gene expression by the untranslated gene regions and other non-coding elements
|
|---|---|
| Published in |
Cellular and Molecular Life Sciences, April 2012
|
| DOI | 10.1007/s00018-012-0990-9 |
| Pubmed ID | |
| Authors |
Lucy W. Barrett, Sue Fletcher, Steve D. Wilton |
| Abstract |
There is now compelling evidence that the complexity of higher organisms correlates with the relative amount of non-coding RNA rather than the number of protein-coding genes. Previously dismissed as "junk DNA", it is the non-coding regions of the genome that are responsible for regulation, facilitating complex temporal and spatial gene expression through the combinatorial effect of numerous mechanisms and interactions working together to fine-tune gene expression. The major regions involved in regulation of a particular gene are the 5' and 3' untranslated regions and introns. In addition, pervasive transcription of complex genomes produces a variety of non-coding transcripts that interact with these regions and contribute to regulation. This review discusses recent insights into the regulatory roles of the untranslated gene regions and non-coding RNAs in the control of complex gene expression, as well as the implications of this in terms of organism complexity and evolution. |
Mendeley readers
The data shown below were compiled from readership statistics for 771 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 5 | <1% |
| United Kingdom | 4 | <1% |
| Switzerland | 2 | <1% |
| Luxembourg | 2 | <1% |
| Netherlands | 2 | <1% |
| Italy | 1 | <1% |
| Canada | 1 | <1% |
| New Zealand | 1 | <1% |
| Australia | 1 | <1% |
| Other | 4 | <1% |
| Unknown | 748 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 184 | 24% |
| Student > Master | 117 | 15% |
| Student > Bachelor | 104 | 13% |
| Researcher | 103 | 13% |
| Student > Doctoral Student | 47 | 6% |
| Other | 74 | 10% |
| Unknown | 142 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 261 | 34% |
| Biochemistry, Genetics and Molecular Biology | 225 | 29% |
| Medicine and Dentistry | 37 | 5% |
| Computer Science | 14 | 2% |
| Chemistry | 14 | 2% |
| Other | 59 | 8% |
| Unknown | 161 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 15. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 February 2024.
All research outputs
#2,396,006
of 26,017,215 outputs
Outputs from Cellular and Molecular Life Sciences
#310
of 6,041 outputs
Outputs of similar age
#14,348
of 179,517 outputs
Outputs of similar age from Cellular and Molecular Life Sciences
#3
of 51 outputs
Altmetric has tracked 26,017,215 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 90th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 6,041 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.9. This one has done particularly well, scoring higher than 94% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 179,517 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 91% of its contemporaries.
We're also able to compare this research output to 51 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 92% of its contemporaries.