| Title |
Arsenic Exposure and Cardiovascular Disorders: An Overview
|
|---|---|
| Published in |
Cardiovascular Toxicology, September 2009
|
| DOI | 10.1007/s12012-009-9050-6 |
| Pubmed ID | |
| Authors |
Pitchai Balakumar, Jagdeep Kaur |
| Abstract |
The incidence of arsenic toxicity has been observed in various countries including Taiwan, Bangladesh, India, Argentina, Australia, Chile, China, Hungary, Peru, Thailand, Mexico and United States of America. Arsenic is a ubiquitous element present in drinking water, and its exposure is associated with various cardiovascular disorders. Arsenic exposure plays a key role in the pathogenesis of vascular endothelial dysfunction as it inactivates endothelial nitric oxide synthase, leading to reduction in the generation and bioavailability of nitric oxide. In addition, the chronic arsenic exposure induces high oxidative stress, which may affect the structure and function of cardiovascular system. Further, the arsenic exposure has been noted to induce atherosclerosis by increasing the platelet aggregation and reducing fibrinolysis. Moreover, arsenic exposure may cause arrhythmia by increasing the QT interval and accelerating the cellular calcium overload. The chronic exposure to arsenic upregulates the expression of tumor necrosis factor-alpha, interleukin-1, vascular cell adhesion molecule and vascular endothelial growth factor to induce cardiovascular pathogenesis. The present review critically discussed the detrimental role of arsenic in the cardiovascular system. |
Mendeley readers
The data shown below were compiled from readership statistics for 121 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 2% |
| Mexico | 1 | <1% |
| Spain | 1 | <1% |
| Argentina | 1 | <1% |
| Unknown | 115 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 25 | 21% |
| Student > Master | 15 | 12% |
| Researcher | 13 | 11% |
| Student > Bachelor | 13 | 11% |
| Student > Doctoral Student | 9 | 7% |
| Other | 21 | 17% |
| Unknown | 25 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 19 | 16% |
| Agricultural and Biological Sciences | 15 | 12% |
| Pharmacology, Toxicology and Pharmaceutical Science | 12 | 10% |
| Biochemistry, Genetics and Molecular Biology | 9 | 7% |
| Environmental Science | 9 | 7% |
| Other | 29 | 24% |
| Unknown | 28 | 23% |
Attention Score in Context
This research output has an Altmetric Attention Score of 222. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 July 2023.
All research outputs
#158,325
of 24,026,368 outputs
Outputs from Cardiovascular Toxicology
#2
of 296 outputs
Outputs of similar age
#319
of 96,599 outputs
Outputs of similar age from Cardiovascular Toxicology
#1
of 1 outputs
Altmetric has tracked 24,026,368 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 296 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.7. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 96,599 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them