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UCHL1 is a Parkinson's disease susceptibility gene

Overview of attention for article published in Annals of Neurology, March 2004
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  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (85th percentile)
  • Average Attention Score compared to outputs of the same age and source

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1 blog
twitter
2 X users

Citations

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228 Dimensions

Readers on

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125 Mendeley
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1 CiteULike
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Title
UCHL1 is a Parkinson's disease susceptibility gene
Published in
Annals of Neurology, March 2004
DOI 10.1002/ana.20017
Pubmed ID
Authors

Demetrius M. Maraganore, Timothy G. Lesnick, Alexis Elbaz, Marie‐Christine Chartier‐Harlin, Thomas Gasser, Rejko Krüger, Nobutaka Hattori, George D. Mellick, Aldo Quattrone, Jun‐Ichi Satoh, Taksushi Toda, Jian Wang, John P.A. Ioannidis, Mariza de Andrade, Walter A. Rocca, the UCHL1 Global Genetics Consortium

Abstract

The reported inverse association between the S18Y variant of the ubiquitin carboxy-terminal hydrolase L1 (UCHL1) gene and Parkinson's disease (PD) has strong biological plausibility. If confirmed, genetic association of this variant with PD may support molecular targeting of the UCHL1 gene and its product as a therapeutic strategy for PD. In this light, we performed a collaborative pooled analysis of individual-level data from all 11 published studies of the UCHL1 S18Y gene variant and PD. There were 1,970 cases and 2,224 unrelated controls. We found a statistically significant inverse association of S18Y with PD. Carriers of the variant allele (Y/Y plus Y/S vs S/S) had an odds ratio (OR) of 0.84 (95% confidence interval [CI], 0.73-0.95) and homozygotes for the variant allele (Y/Y vs S/S plus Y/S) had an OR of 0.71 (95% CI, 0.57-0.88). There was a linear trend in the log OR consistent with a gene dose effect (p = 0.01). The inverse association was most apparent for young cases compared with young controls. There was no evidence for publication bias and the associations remained significant after excluding the first published, hypothesis-generating study. These findings confirm that UCHL1 is a susceptibility gene for PD and a potential target for disease-modifying therapies.

X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 125 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 4 3%
France 2 2%
United States 1 <1%
Unknown 118 94%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 28 22%
Student > Bachelor 20 16%
Student > Master 17 14%
Researcher 12 10%
Student > Postgraduate 7 6%
Other 23 18%
Unknown 18 14%
Readers by discipline Count As %
Agricultural and Biological Sciences 38 30%
Medicine and Dentistry 20 16%
Biochemistry, Genetics and Molecular Biology 16 13%
Neuroscience 13 10%
Pharmacology, Toxicology and Pharmaceutical Science 3 2%
Other 11 9%
Unknown 24 19%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 August 2019.
All research outputs
#4,087,117
of 24,520,935 outputs
Outputs from Annals of Neurology
#1,883
of 5,544 outputs
Outputs of similar age
#8,432
of 60,190 outputs
Outputs of similar age from Annals of Neurology
#3
of 5 outputs
Altmetric has tracked 24,520,935 research outputs across all sources so far. Compared to these this one has done well and is in the 83rd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,544 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.5. This one has gotten more attention than average, scoring higher than 65% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 60,190 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 85% of its contemporaries.
We're also able to compare this research output to 5 others from the same source and published within six weeks on either side of this one. This one has scored higher than 2 of them.