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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Re-analysis of public genetic data reveals a rare X-chromosomal variant associated with type 2 diabetes
|
|---|---|
| Published in |
Nature Communications, January 2018
|
| DOI | 10.1038/s41467-017-02380-9 |
| Pubmed ID | |
| Authors |
Sílvia Bonàs-Guarch, Marta Guindo-Martínez, Irene Miguel-Escalada, Niels Grarup, David Sebastian, Elias Rodriguez-Fos, Friman Sánchez, Mercè Planas-Fèlix, Paula Cortes-Sánchez, Santi González, Pascal Timshel, Tune H. Pers, Claire C. Morgan, Ignasi Moran, Goutham Atla, Juan R. González, Montserrat Puiggros, Jonathan Martí, Ehm A. Andersson, Carlos Díaz, Rosa M. Badia, Miriam Udler, Aaron Leong, Varindepal Kaur, Jason Flannick, Torben Jørgensen, Allan Linneberg, Marit E. Jørgensen, Daniel R. Witte, Cramer Christensen, Ivan Brandslund, Emil V. Appel, Robert A. Scott, Jian’an Luan, Claudia Langenberg, Nicholas J. Wareham, Oluf Pedersen, Antonio Zorzano, Jose C Florez, Torben Hansen, Jorge Ferrer, Josep Maria Mercader, David Torrents |
| Abstract |
The reanalysis of existing GWAS data represents a powerful and cost-effective opportunity to gain insights into the genetics of complex diseases. By reanalyzing publicly available type 2 diabetes (T2D) genome-wide association studies (GWAS) data for 70,127 subjects, we identify seven novel associated regions, five driven by common variants (LYPLAL1, NEUROG3, CAMKK2, ABO, and GIP genes), one by a low-frequency (EHMT2), and one driven by a rare variant in chromosome Xq23, rs146662057, associated with a twofold increased risk for T2D in males. rs146662057 is located within an active enhancer associated with the expression of Angiotensin II Receptor type 2 gene (AGTR2), a modulator of insulin sensitivity, and exhibits allelic specific activity in muscle cells. Beyond providing insights into the genetics and pathophysiology of T2D, these results also underscore the value of reanalyzing publicly available data using novel genetic resources and analytical approaches. |
X Demographics
The data shown below were collected from the profiles of 54 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 12 | 22% |
| Spain | 7 | 13% |
| United Kingdom | 4 | 7% |
| Denmark | 3 | 6% |
| Sweden | 2 | 4% |
| Germany | 1 | 2% |
| Finland | 1 | 2% |
| France | 1 | 2% |
| Mexico | 1 | 2% |
| Other | 3 | 6% |
| Unknown | 19 | 35% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 29 | 54% |
| Scientists | 22 | 41% |
| Practitioners (doctors, other healthcare professionals) | 3 | 6% |
Mendeley readers
The data shown below were compiled from readership statistics for 151 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 151 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 34 | 23% |
| Student > Ph. D. Student | 21 | 14% |
| Student > Bachelor | 19 | 13% |
| Student > Master | 14 | 9% |
| Student > Doctoral Student | 8 | 5% |
| Other | 17 | 11% |
| Unknown | 38 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 44 | 29% |
| Medicine and Dentistry | 21 | 14% |
| Agricultural and Biological Sciences | 20 | 13% |
| Nursing and Health Professions | 5 | 3% |
| Earth and Planetary Sciences | 3 | 2% |
| Other | 13 | 9% |
| Unknown | 45 | 30% |
Attention Score in Context
This research output has an Altmetric Attention Score of 53. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 April 2021.
All research outputs
#742,417
of 24,187,394 outputs
Outputs from Nature Communications
#12,580
of 51,438 outputs
Outputs of similar age
#18,350
of 448,834 outputs
Outputs of similar age from Nature Communications
#361
of 1,232 outputs
Altmetric has tracked 24,187,394 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 96th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 51,438 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 56.3. This one has done well, scoring higher than 75% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 448,834 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 95% of its contemporaries.
We're also able to compare this research output to 1,232 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 70% of its contemporaries.