Title |
High affinity binding of3H-paroxetine and3H-imipramine to rat neuronal membranes
|
---|---|
Published in |
Psychopharmacology, July 1986
|
DOI | 10.1007/bf02412117 |
Pubmed ID | |
Authors |
Erling T. Mellerup, Per Plenge |
Abstract |
Paroxetine is the most potent and one of the most specific serotonin uptake inhibitors. High-affinity 3H-paroxetine and 3H-imipramine binding was compared in rat neuronal membranes. The KD value for 3H-paroxetine binding to neuronal membranes was 0.08 nM, which is exactly the same value as with platelet membranes. The KD value for 3H-imipramine binding to neuronal membranes was about 4 nM, which is higher than the KD value for 3H-imipramine binding to platelet membranes (0.5 nM). The results indicated that the 3H-paroxetine binding site is identical in neuronal membranes and in platelet membranes; this binding site is probably located on the serotonin transport mechanism. In addition, part of the high-affinity 3H-imipramine binding to neuronal membranes is probably located on the serotonin transport mechanism, but another part is located elsewhere. Furthermore the polypeptides containing the 3H-imipramine binding sites may not be identical in neuronal and platelet membranes. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 11 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 3 | 27% |
Lecturer | 1 | 9% |
Professor | 1 | 9% |
Student > Bachelor | 1 | 9% |
Researcher | 1 | 9% |
Other | 1 | 9% |
Unknown | 3 | 27% |
Readers by discipline | Count | As % |
---|---|---|
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Chemistry | 2 | 18% |
Agricultural and Biological Sciences | 1 | 9% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 9% |
Neuroscience | 1 | 9% |
Other | 1 | 9% |
Unknown | 3 | 27% |