| Title |
Nucleolus: the fascinating nuclear body
|
|---|---|
| Published in |
Histochemistry and Cell Biology, November 2007
|
| DOI | 10.1007/s00418-007-0359-6 |
| Pubmed ID | |
| Authors |
Valentina Sirri, Silvio Urcuqui-Inchima, Pascal Roussel, Danièle Hernandez-Verdun |
| Abstract |
Nucleoli are the prominent contrasted structures of the cell nucleus. In the nucleolus, ribosomal RNAs are synthesized, processed and assembled with ribosomal proteins. RNA polymerase I synthesizes the ribosomal RNAs and this activity is cell cycle regulated. The nucleolus reveals the functional organization of the nucleus in which the compartmentation of the different steps of ribosome biogenesis is observed whereas the nucleolar machineries are in permanent exchange with the nucleoplasm and other nuclear bodies. After mitosis, nucleolar assembly is a time and space regulated process controlled by the cell cycle. In addition, by generating a large volume in the nucleus with apparently no RNA polymerase II activity, the nucleolus creates a domain of retention/sequestration of molecules normally active outside the nucleolus. Viruses interact with the nucleolus and recruit nucleolar proteins to facilitate virus replication. The nucleolus is also a sensor of stress due to the redistribution of the ribosomal proteins in the nucleoplasm by nucleolus disruption. The nucleolus plays several crucial functions in the nucleus: in addition to its function as ribosome factory of the cells it is a multifunctional nuclear domain, and nucleolar activity is linked with several pathologies. Perspectives on the evolution of this research area are proposed. |
Mendeley readers
The data shown below were compiled from readership statistics for 364 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 3 | <1% |
| Spain | 2 | <1% |
| United States | 2 | <1% |
| France | 2 | <1% |
| Italy | 1 | <1% |
| Sweden | 1 | <1% |
| Portugal | 1 | <1% |
| United Kingdom | 1 | <1% |
| Netherlands | 1 | <1% |
| Other | 2 | <1% |
| Unknown | 348 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 103 | 28% |
| Researcher | 60 | 16% |
| Student > Master | 43 | 12% |
| Student > Bachelor | 38 | 10% |
| Student > Doctoral Student | 14 | 4% |
| Other | 42 | 12% |
| Unknown | 64 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 140 | 38% |
| Biochemistry, Genetics and Molecular Biology | 101 | 28% |
| Medicine and Dentistry | 17 | 5% |
| Chemistry | 9 | 2% |
| Neuroscience | 9 | 2% |
| Other | 18 | 5% |
| Unknown | 70 | 19% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 September 2023.
All research outputs
#8,759,452
of 25,837,817 outputs
Outputs from Histochemistry and Cell Biology
#315
of 1,246 outputs
Outputs of similar age
#44,292
of 169,778 outputs
Outputs of similar age from Histochemistry and Cell Biology
#2
of 5 outputs
Altmetric has tracked 25,837,817 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,246 research outputs from this source. They receive a mean Attention Score of 3.8. This one is in the 34th percentile – i.e., 34% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 169,778 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 17th percentile – i.e., 17% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 5 others from the same source and published within six weeks on either side of this one. This one has scored higher than 3 of them.