| Title |
Physiology of IgA and IgA Deficiency
|
|---|---|
| Published in |
Journal of Clinical Immunology, September 2001
|
| DOI | 10.1023/a:1012241117984 |
| Pubmed ID | |
| Authors |
Charlotte Cunningham-Rundles |
| Abstract |
Although secretory immunoglobulin A (IgA) is important in mucosal immunity. selective IgA deficiency is the most common primary immunodeficiency of humans. In most cases this defect is not associated with any illness. The reasons for this are unknown, but other immunological compensations might provide sufficient or complete restitution. Alternatively, it is possible that IgA deficiency alone may not predispose to disease, but additional immunological abnormalities might be present in symptomatic individuals. Some IgA-deficient individuals have a reduced antibody response to immunizations (even with normal IgG and IgM levels) and others have deficient responses to bacterial polysaccharides when IgG subclass levels are normal. The physiological role of IgA, the frequency and causes of IgA deficiency, the diseases associated with its absence, and current limited understanding of the pathogenesis of selective IgA deficiency will be reviewed. |
Mendeley readers
The data shown below were compiled from readership statistics for 171 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Portugal | 1 | <1% |
| Colombia | 1 | <1% |
| Germany | 1 | <1% |
| Tanzania, United Republic of | 1 | <1% |
| Ireland | 1 | <1% |
| Australia | 1 | <1% |
| Mexico | 1 | <1% |
| Unknown | 164 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 30 | 18% |
| Student > Ph. D. Student | 29 | 17% |
| Student > Bachelor | 24 | 14% |
| Student > Master | 19 | 11% |
| Student > Doctoral Student | 12 | 7% |
| Other | 27 | 16% |
| Unknown | 30 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 53 | 31% |
| Agricultural and Biological Sciences | 30 | 18% |
| Biochemistry, Genetics and Molecular Biology | 15 | 9% |
| Immunology and Microbiology | 15 | 9% |
| Sports and Recreations | 5 | 3% |
| Other | 17 | 10% |
| Unknown | 36 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 September 2021.
All research outputs
#8,535,472
of 25,374,917 outputs
Outputs from Journal of Clinical Immunology
#683
of 1,809 outputs
Outputs of similar age
#14,139
of 40,837 outputs
Outputs of similar age from Journal of Clinical Immunology
#1
of 1 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,809 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.6. This one is in the 47th percentile – i.e., 47% of its peers scored the same or lower than it.
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We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them