Chapter title |
G-Quadruplexes and DNA Replication Origins
|
---|---|
Chapter number | 13 |
Book title |
DNA Replication
|
Published in |
Advances in experimental medicine and biology, January 2017
|
DOI | 10.1007/978-981-10-6955-0_13 |
Pubmed ID | |
Book ISBNs |
978-9-81-106954-3, 978-9-81-106955-0
|
Authors |
Marie-Noëlle Prioleau, Prioleau, Marie-Noëlle |
Abstract |
DNA replication ensures the accurate duplication of the genome at each cell cycle. During S phase, tens of thousands of replication origins throughout the vertebrate genome are activated according to a spatiotemporal program. The genome-wide mapping of origins in several model systems has identified G-quadruplexes-higher-order DNA structures formed from G-rich sequences-as potential key regulators of origin activity. Here, I describe genetic experiments demonstrating the role of G-quadruplexes in origin function. I discuss the different means by which G-quadruplexes might regulate origin function. Finally, comparisons of replicon organization in the three domains of life suggest that G-quadruplexes may have retained a conserved role in origin function during evolution. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
France | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 35 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 9 | 26% |
Professor | 5 | 14% |
Student > Master | 4 | 11% |
Student > Ph. D. Student | 3 | 9% |
Student > Doctoral Student | 1 | 3% |
Other | 3 | 9% |
Unknown | 10 | 29% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 16 | 46% |
Agricultural and Biological Sciences | 4 | 11% |
Nursing and Health Professions | 1 | 3% |
Immunology and Microbiology | 1 | 3% |
Unknown | 13 | 37% |