| Title |
Subtype-selective GABAA receptor mimetics—novel antihyperalgesic agents?
|
|---|---|
| Published in |
Journal of Molecular Medicine, March 2009
|
| DOI | 10.1007/s00109-009-0454-3 |
| Pubmed ID | |
| Authors |
Hanns Ulrich Zeilhofer, Robert Witschi, Katharina Hösl |
| Abstract |
Agonists at the benzodiazepine-binding site of ionotropic gamma-aminobutyric acid (GABA(A)) receptors are in clinical use as hypnotics, anxiolytics, and anticonvulsants since the early 1960. Analgesic effects of classical benzodiazepines have occasionally been reported in certain subgroups of patients suffering from chronic pain or after spinal delivery through intrathecal catheters. However, these drugs are generally not considered as analgesics but should in fact be avoided in patients with chronic pain. Recent evidence from genetically modified mice now indicates that agents targeting only a subset of benzodiazepine (GABA(A)) receptors should provide pronounced antihyperalgesic activity against inflammatory and neuropathic pain. Several such compounds have been developed recently, which exhibit significant antihyperalgesia in mice and rats and appear to be devoid of the typical side-effects of classical benzodiazepines. |
Mendeley readers
The data shown below were compiled from readership statistics for 33 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Austria | 2 | 6% |
| Germany | 1 | 3% |
| United States | 1 | 3% |
| Unknown | 29 | 88% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 7 | 21% |
| Student > Master | 7 | 21% |
| Student > Bachelor | 4 | 12% |
| Professor > Associate Professor | 4 | 12% |
| Researcher | 3 | 9% |
| Other | 6 | 18% |
| Unknown | 2 | 6% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 10 | 30% |
| Medicine and Dentistry | 6 | 18% |
| Neuroscience | 5 | 15% |
| Pharmacology, Toxicology and Pharmaceutical Science | 4 | 12% |
| Chemistry | 2 | 6% |
| Other | 3 | 9% |
| Unknown | 3 | 9% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 April 2014.
All research outputs
#7,451,942
of 22,782,096 outputs
Outputs from Journal of Molecular Medicine
#504
of 1,550 outputs
Outputs of similar age
#32,934
of 93,235 outputs
Outputs of similar age from Journal of Molecular Medicine
#5
of 12 outputs
Altmetric has tracked 22,782,096 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,550 research outputs from this source. They receive a mean Attention Score of 5.0. This one is in the 35th percentile – i.e., 35% of its peers scored the same or lower than it.
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We're also able to compare this research output to 12 others from the same source and published within six weeks on either side of this one. This one is in the 25th percentile – i.e., 25% of its contemporaries scored the same or lower than it.