Title |
Anti-cancer gold(I) phosphine complexes: Cyclic trimers and tetramers containing the P-Au-P moiety
|
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Published in |
Journal of Inorganic Biochemistry, June 2017
|
DOI | 10.1016/j.jinorgbio.2017.06.010 |
Pubmed ID | |
Authors |
T. Srinivasa Reddy, Steven H. Privér, Nedaossadat Mirzadeh, Suresh K. Bhargava |
Abstract |
We report the application of cationic tri- and tetra-nuclear gold(I) phosphine complexes [Au3(μ-dppen)3]X3 and [Au4(μ-dppa)4]X4 (X=OTf, PF6) [OTf=trifluoromethanesulfonate, dppen=trans-1,2-bis(diphenylphosphino)ethene, dppa=bis(diphenylphosphino)acetylene] for cancer treatment. The results of cytotoxicity tests on four different cancer cells [prostate (DU145), cervical (HeLa), breast (MDAMB-231) and fibro sarcoma (HT1080)] indicate these complexes possess remarkable tumor cell growth inhibitory effects and high selectivity towards cancer cells. The anti-tumor mechanism of the tri- and tetra-nuclear gold(I) complexes has also been investigated. |
Mendeley readers
Geographical breakdown
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Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 8 | 22% |
Student > Ph. D. Student | 6 | 16% |
Professor > Associate Professor | 4 | 11% |
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Other | 1 | 3% |
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Other | 2 | 5% |
Unknown | 13 | 35% |