| Title |
Acquired immunodeficiency syndrome and the blood-brain barrier
|
|---|---|
| Published in |
Journal of NeuroVirology, March 2009
|
| DOI | 10.1080/13550280902769764 |
| Pubmed ID | |
| Authors |
Nathan S. Ivey, Andrew G. MacLean, Andrew A. Lackner |
| Abstract |
The blood-brain barrier (BBB) plays a critical role in normal physiology of the central nervous system by regulating what reaches the brain from the periphery. The BBB also plays a major role in neurologic disease including neuropathologic sequelae associated with infection by human immunodeficiency virus (HIV) in humans and the closely related simian immunodeficiency virus (SIV) in macaques. In this review, we provide an overview of the function, structure, and components of the BBB, followed by a more detailed discussion of the subcellular structures and regulation of the tight junction. We then discuss the ways in which HIV/SIV affects the BBB, largely through infection of monocytes/macrophages, and how infected macrophages crossing the BBB ultimately results in breakdown of the barrier. |
Mendeley readers
The data shown below were compiled from readership statistics for 74 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 1% |
| Unknown | 73 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 15 | 20% |
| Researcher | 13 | 18% |
| Student > Bachelor | 8 | 11% |
| Student > Doctoral Student | 5 | 7% |
| Other | 5 | 7% |
| Other | 12 | 16% |
| Unknown | 16 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 17 | 23% |
| Medicine and Dentistry | 14 | 19% |
| Biochemistry, Genetics and Molecular Biology | 8 | 11% |
| Immunology and Microbiology | 7 | 9% |
| Neuroscience | 4 | 5% |
| Other | 6 | 8% |
| Unknown | 18 | 24% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 April 2016.
All research outputs
#8,262,107
of 25,374,647 outputs
Outputs from Journal of NeuroVirology
#239
of 1,018 outputs
Outputs of similar age
#37,725
of 108,601 outputs
Outputs of similar age from Journal of NeuroVirology
#1
of 3 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one has received more attention than most of these and is in the 66th percentile.
So far Altmetric has tracked 1,018 research outputs from this source. They receive a mean Attention Score of 4.4. This one has done well, scoring higher than 75% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 108,601 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 64% of its contemporaries.
We're also able to compare this research output to 3 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them