Title |
Norovirus Gastroenteritis Outbreak with a Secretor-independent Susceptibility Pattern, Sweden - Volume 16, Number 1—January 2010 - Emerging Infectious Diseases journal - CDC
|
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Published in |
Emerging Infectious Diseases, January 2010
|
DOI | 10.3201/eid1601.090633 |
Pubmed ID | |
Authors |
Johan Nordgren, Elin Kindberg, Per Eric Lindgren, Andreas Matussek, Lennart Svensson |
Abstract |
Norovirus (NoV) is recognized as the commonest cause of acute gastroenteritis among adults. Susceptibility to disease has been associated with histo-blood group antigens and secretor status; nonsecretors are almost completely resistant to disease. We report a foodborne outbreak of GI.3 NoV gastroenteritis that affected 33/83 (40%) persons. Symptomatic disease was as likely to develop in nonsecretors as in secretors (odds ratio [OR] 1.41, 95% confidence interval [CI] 0.46-4.36 vs. OR 0.71, 95% CI 0.23-2.18, p = 0.57). Moreover, no statistical difference in susceptibility was found between persons of different Lewis or ABO phenotypes. The capsid gene of the outbreak strain shares high amino acid homology with the Kashiwa645 GI.3 strain, previously shown to recognize nonsecretor saliva, as well as synthetic Lewis a. This norovirus outbreak affected persons regardless of secretor status or Lewis or ABO phenotypes. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Japan | 5 | 29% |
France | 1 | 6% |
Sweden | 1 | 6% |
Unknown | 10 | 59% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 17 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 1% |
Australia | 1 | 1% |
Brazil | 1 | 1% |
Unknown | 69 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 16 | 22% |
Student > Ph. D. Student | 14 | 19% |
Student > Bachelor | 11 | 15% |
Student > Master | 8 | 11% |
Student > Postgraduate | 6 | 8% |
Other | 10 | 14% |
Unknown | 7 | 10% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 27 | 38% |
Medicine and Dentistry | 12 | 17% |
Biochemistry, Genetics and Molecular Biology | 10 | 14% |
Immunology and Microbiology | 4 | 6% |
Engineering | 2 | 3% |
Other | 6 | 8% |
Unknown | 11 | 15% |