Title |
Parameters Associated With Mandibular Osteoradionecrosis
|
---|---|
Published in |
American Journal of Clinical Oncology: Cancer Clinical Trials, December 2018
|
DOI | 10.1097/coc.0000000000000424 |
Pubmed ID | |
Authors |
William M Mendenhall, Carlos Suárez, Eric M Genden, Remco de Bree, Primož Strojan, Johannes A Langendijk, Antti A Mäkitie, Robert Smee, Avraham Eisbruch, Anne W M Lee, Alessandra Rinaldo, Alfio Ferlito |
Abstract |
The objective of this review is to discuss factors related to the risk of osteoradionecrosis (ORN) and how to minimize the likelihood of this complication. A PubMed search for publications pertaining to ORN within the last 3 years was conducted revealing 44 publications. The bibliographies of these publications were reviewed to identify additional references spanning a longer time period. The incidence of ORN is 5% to 10% with a median latency period of 1 to 2 years or less. The likelihood of ORN depends on a number of factors including primary site and extent of disease, dental status, treatment modality, radiotherapy (RT) dose, volume of mandible included in the planning target volume, RT fractionation schedule and technique, and teeth extractions. The risk of ORN may be reduced by limiting the RT dose and volume of mandible irradiated without increasing the risk of a local-regional recurrence due to a marginal miss. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Finland | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 50% |
Practitioners (doctors, other healthcare professionals) | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 53 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 7 | 13% |
Other | 6 | 11% |
Researcher | 6 | 11% |
Student > Postgraduate | 4 | 8% |
Student > Bachelor | 4 | 8% |
Other | 10 | 19% |
Unknown | 16 | 30% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 26 | 49% |
Biochemistry, Genetics and Molecular Biology | 2 | 4% |
Engineering | 2 | 4% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 2% |
Agricultural and Biological Sciences | 1 | 2% |
Other | 3 | 6% |
Unknown | 18 | 34% |